S
Shintaro Kinugawa
Researcher at Hokkaido University
Publications - 202
Citations - 9872
Shintaro Kinugawa is an academic researcher from Hokkaido University. The author has contributed to research in topics: Heart failure & Skeletal muscle. The author has an hindex of 46, co-authored 189 publications receiving 8369 citations. Previous affiliations of Shintaro Kinugawa include Kyushu University & Hokkaido University of Education.
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Journal ArticleDOI
Oxidative stress and heart failure
TL;DR: Oxidative stress is involved in the pathophysiology of HF in the heart as well as in the skeletal muscle, and a better understanding of these mechanisms may enable the development of novel and effective therapeutic strategies against HF.
Journal ArticleDOI
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Hideo Utsumi,Dongchon Kang,Nobutaka Hattori,Koji Uchida,Ken ichi Arimura,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: Direct evidence is provided for the involvement of ROS in the mitochondrial origin of HF myocytes, which might be responsible for both contractile dysfunction and structural damage to the myocardium.
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Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Nobuhiro Suematsu,Shunji Hayashidani,Kazuhiro Ichikawa,Hideo Utsumi,Youji Machida,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: There was a significant positive relation between myocardial ROS level and left ventricular contractile dysfunction and, in the failing myocardium, *OH was produced as a reactive product of *O(2)(-) and H(2)O( 2), which might play an important role inleft ventricular failure.
Journal ArticleDOI
JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ―
Hiroyuki Tsutsui,Mitsuaki Isobe,Hiroshi Ito,Ken Okumura,Minoru Ono,Masafumi Kitakaze,Koichiro Kinugawa,Yasuki Kihara,Yoichi Goto,Issei Komuro,Yoshikatsu Saiki,Yoshihiko Saito,Yasushi Sakata,Naoki Sato,Yoshiki Sawa,Akira Shiose,Wataru Shimizu,Hiroaki Shimokawa,Yoshihiko Seino,Koichi Node,Taiki Higo,Atsushi Hirayama,Miyuki Makaya,Tohru Masuyama,Toyoaki Murohara,Shin-ichi Momomura,Masafumi Yano,Kenji Yamazaki,Kazuhiro Yamamoto,Tsutomu Yoshikawa,Michihiro Yoshimura,Masatoshi Akiyama,Toshihisa Anzai,Shiro Ishihara,Takayuki Inomata,Teruhiko Imamura,Yu-ki Iwasaki,Tomohito Ohtani,Katsuya Onishi,Takatoshi Kasai,Mahoto Kato,Makoto Kawai,Yoshiharu Kinugasa,Shintaro Kinugawa,Toru Kuratani,Shigeki Kobayashi,Yasuhiko Sakata,Atsushi Tanaka,Koichi Toda,Takashi Noda,Kotaro Nochioka,Masaru Hatano,Takayuki Hidaka,Takeo Fujino,Shigeru Makita,Osamu Yamaguchi,Uichi Ikeda,Takeshi Kimura,Shun Kohsaka,Masami Kosuge,Masakazu Yamagishi,Akira Yamashina +61 more
TL;DR: This English language document is a revised digest version of Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure (JCS 2017/JHFS 2017) reported at the Japanese Circulation Society Joint Working Groups performed in 2017.
Journal Article
Oxidative stress and heart failure
TL;DR: The regulation of mitochondrial oxidative stress or manipulation of TFAM protein may provide a novel therapeutic strategy of HF.