S
Shyam Karki
Researcher at Bristol-Myers Squibb
Publications - 9
Citations - 255
Shyam Karki is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Dissolution testing & Microcrystalline cellulose. The author has an hindex of 5, co-authored 9 publications receiving 59 citations. Previous affiliations of Shyam Karki include Celgene.
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Journal ArticleDOI
Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies.
Sonal V Bhujbal,Biplob Mitra,Uday Jain,Yuchuan Gong,Anjali Agrawal,Shyam Karki,Lynne S. Taylor,Sumit Kumar,Qi Tony Zhou +8 more
TL;DR: This review provides an updated overview of manufacturing techniques for preparing ASDs, and selection strategies are proposed to identify suitable manufacturing methods, which may aid in the development of ASDs with satisfactory physical stability.
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3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment.
Atabak Ghanizadeh Tabriz,Uttom Nandi,Andrew P. Hurt,Ho-Wah Hui,Shyam Karki,Yuchuan Gong,Sumit Kumar,Dennis Douroumis +7 more
TL;DR: The work illustrated the potential application of FDM technology in the development of oral fixed dose combination for personalized clinical treatment by minimizing the degradation of RFC in the acidic condition and potentially avoid drug-drug interaction.
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Decoding the small size challenges of mini-tablets for enhanced dose flexibility and micro-dosing.
Biplob Mitra,Prajwal Thool,Saikishore Meruva,J. Alex Aycinena,Jianmin Li,Jhalak Patel,Kuldip Patel,Anjali Agarwal,Shyam Karki,William Bowen +9 more
TL;DR: In this article, a platform formulation with 60, 80, and 100 µm (particle size D6,3) ibuprofen at 3, 14, and 25% loadings were directly compressed into 1.2, 1.5, 2, and 2.5 µm diameter mini-tablets.
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Formulation and performance of Irbesartan nanocrystalline suspension and granulated or bead-layered dried powders - Part I.
Saikishore Meruva,Prajwal Thool,Shawreen Shah,Shyam Karki,William Bowen,Ghosh Indrajit,Sumit Kumar +6 more
TL;DR: Optized Irbesartan nanocrystalline suspension showed superior in vitro dissolution profile compared to unmilled suspension and remained crystalline post drying, and drug concentration and type of stabilizer were found to be significant in particle size reduction.
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Development of low dose micro-tablets by high shear wet granulation process.
Shashwat Gupta,Prajwal Thool,Saikishore Meruva,Jianmin Li,Jhalak Patel,Anjali Agrawal,Shyam Karki,William Bowen,Biplob Mitra +8 more
TL;DR: This study provides a framework for developing low dose micro-tablets with acceptable quality attributes using HSWG process for micro-dosing, enhanced dose flexibility, and decreased excipient burden.