S
Sibylle Jäger
Researcher at Harvard University
Publications - 10
Citations - 5826
Sibylle Jäger is an academic researcher from Harvard University. The author has contributed to research in topics: Coactivator & Mitochondrial biogenesis. The author has an hindex of 6, co-authored 7 publications receiving 5348 citations. Previous affiliations of Sibylle Jäger include University of Stuttgart.
Papers
More filters
Journal ArticleDOI
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
TL;DR: The data indicate that AMPK phosphorylation of PGC-1α initiates many of the important gene regulatory functions of AMPK in skeletal muscle.
Journal ArticleDOI
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
Julie St-Pierre,Stavit Drori,Marc Uldry,Jessica M. Silvaggi,James Rhee,Sibylle Jäger,Christoph Handschin,Kangni Zheng,Jiandie D. Lin,Wenli Yang,David Simon,Robert M. Bachoo,Robert M. Bachoo,Bruce M. Spiegelman +13 more
TL;DR: Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins.
Journal ArticleDOI
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Jiandie D. Lin,Pei Hsuan Wu,Paul T. Tarr,Katrin S. Lindenberg,Julie St-Pierre,Chen-Yu Zhang,Vamsi K. Mootha,Sibylle Jäger,Claudia R. Vianna,Richard M. Reznick,Libin Cui,Monia Manieri,Mi X. Donovan,Zhidan Wu,Marcus P. Cooper,Melina C. Fan,Lindsay M. Rohas,Ann Marie Zavacki,Saverio Cinti,Gerald I. Shulman,Bradford B. Lowell,Dimitri Krainc,Bruce M. Spiegelman +22 more
TL;DR: A central role for PGC-1alpha in the control of energy metabolism is illustrated but also novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis are revealed.
Journal ArticleDOI
The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
Michael Groll,Wolfgang Heinemeyer,Sibylle Jäger,Tobias C. Ullrich,Matthias Bochtler,Dieter H. Wolf,Robert Huber +6 more
TL;DR: A gallery of proteasome mutants that contain active site residues in the context of the inactive subunits beta3(Pup3), beta6(Pre7), and beta7(Pre4) show that the presence of Gly-1, Thr1, Asp17, Lys33, Ser129, AsP166, and Ser169 is not sufficient to generate activity.
Journal ArticleDOI
A fundamental system of cellular energy homeostasis regulated by PGC-1α
Lindsay M. Rohas,Julie St-Pierre,Marc Uldry,Sibylle Jäger,Christoph Handschin,Bruce M. Spiegelman +5 more
TL;DR: It is shown that mammalian cells respond to a partial chemical uncoupling of mitochondrial oxidative phosphorylation with a decrease in ATP levels, which recovers over several hours to control levels.