L
Lindsay M. Rohas
Researcher at Harvard University
Publications - 4
Citations - 2496
Lindsay M. Rohas is an academic researcher from Harvard University. The author has contributed to research in topics: Mitochondrion & Coactivator. The author has an hindex of 4, co-authored 4 publications receiving 2353 citations.
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Journal ArticleDOI
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Jiandie D. Lin,Pei Hsuan Wu,Paul T. Tarr,Katrin S. Lindenberg,Julie St-Pierre,Chen-Yu Zhang,Vamsi K. Mootha,Sibylle Jäger,Claudia R. Vianna,Richard M. Reznick,Libin Cui,Monia Manieri,Mi X. Donovan,Zhidan Wu,Marcus P. Cooper,Melina C. Fan,Lindsay M. Rohas,Ann Marie Zavacki,Saverio Cinti,Gerald I. Shulman,Bradford B. Lowell,Dimitri Krainc,Bruce M. Spiegelman +22 more
TL;DR: A central role for PGC-1alpha in the control of energy metabolism is illustrated but also novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis are revealed.
Journal ArticleDOI
Transcriptional Control of Brown Fat Determination by PRDM16
Patrick Seale,Shingo Kajimura,Wenli Yang,Sherry Chin,Lindsay M. Rohas,Marc Uldry,Geneviève Tavernier,Geneviève Tavernier,Dominique Langin,Dominique Langin,Bruce M. Spiegelman +10 more
TL;DR: It is shown here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells, indicating that PRDM 16 can control the determination of brown fat fate.
Journal ArticleDOI
A fundamental system of cellular energy homeostasis regulated by PGC-1α
Lindsay M. Rohas,Julie St-Pierre,Marc Uldry,Sibylle Jäger,Christoph Handschin,Bruce M. Spiegelman +5 more
TL;DR: It is shown that mammalian cells respond to a partial chemical uncoupling of mitochondrial oxidative phosphorylation with a decrease in ATP levels, which recovers over several hours to control levels.
Journal ArticleDOI
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1α/LRP130 complex
Marcus P. Cooper,Lishu Qu,Lindsay M. Rohas,Jiandie D. Lin,Wenli Yang,Hediye Erdjument-Bromage,Paul Tempst,Bruce M. Spiegelman +7 more
TL;DR: It is shown that LRP130 is a component of the PGC-1alpha (peroxisome proliferator-activated receptor coactivator 1-alpha) transcriptional coactivators holocomplex and regulates expression of PEPCK (phosphoenolpyruvate carboxykinase), G6P (glucose-6-phosphatase), and certain mitochondrial genes through PGC -1alpha.