S
Sierra H. Root
Researcher at University of Connecticut Health Center
Publications - 10
Citations - 830
Sierra H. Root is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: Population & Cellular differentiation. The author has an hindex of 5, co-authored 8 publications receiving 774 citations. Previous affiliations of Sierra H. Root include University of Connecticut.
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Journal ArticleDOI
NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs
Ren-He Xu,Tori L. Sampsell-Barron,Feng Gu,Sierra H. Root,Ruthann M. Peck,Guangjin Pan,Junying Yu,Jessica Antosiewicz-Bourget,Shulan Tian,Ron Stewart,James A. Thomson +10 more
TL;DR: It is suggested that direct binding of TGFbeta/Activin-responsive SMADs to the NANOG promoter plays an essential role in sustaining human ESC self-renewal.
Journal ArticleDOI
X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.
Yin Shen,Youko Matsuno,Shaun D. Fouse,Nagesh Rao,Sierra H. Root,Ren-He Xu,Matteo Pellegrini,Arthur D. Riggs,Guoping Fan +8 more
TL;DR: It is proposed that XCI status should be routinely checked in subcultures of female hESCs, with cultures displaying XCI markers better suited for use in regenerative medicine.
Journal ArticleDOI
Transcriptional regulation of IL-15 expression during hematopoiesis.
Sara L. Colpitts,Spencer W. Stonier,Thomas A. Stoklasek,Sierra H. Root,Hector L. Aguila,Kimberly S. Schluns,Leo Lefrançois +6 more
TL;DR: It is demonstrated that IL-15 expression is coordinated with cellular fate in myeloid versus lymphoid immune cells and downregulation was Notch-dependent and occurred in a stepwise pattern coincident with increasing maturation and commitment to a T cell fate.
Journal ArticleDOI
A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis
Masanobu Ohishi,Wanida Ono,Noriaki Ono,Richa Khatri,Marilena Marzia,Emma Baker,Sierra H. Root,Tremika L.S. Wilson,Tremika L.S. Wilson,Yukihide Iwamoto,Henry M. Kronenberg,Hector L. Aguila,Louise E. Purton,Louise E. Purton,Ernestina Schipani,Ernestina Schipani +15 more
TL;DR: The findings indicate that the BM is a permissive microenvironment for the differentiation of fibrocyte-like cells and raise the possibility that these cells could contribute to the pathogenesis of BM fibrosis.
Journal ArticleDOI
Perivascular osteoprogenitors are associated with transcortical channels of long bones.
Sierra H. Root,Natalie K.Y. Wee,Sanja Novak,Clifford J. Rosen,Roland Baron,Brya G. Matthews,Brya G. Matthews,Ivo Kalajzic +7 more
TL;DR: It is demonstrated that this stromal population of transcortical perivascular cells (TPCs) can migrate out of cortical bone channels, expand, and differentiate into osteoblasts, therefore serving as a source of progenitors contributing to new bone formation.