S
Silvia Aparicio
Researcher at Spanish National Research Council
Publications - 4
Citations - 2470
Silvia Aparicio is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gene & Endothelial stem cell. The author has an hindex of 4, co-authored 4 publications receiving 2239 citations.
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Journal ArticleDOI
Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
Coro Paisán-Ruiz,Shushant Jain,E. Whitney Evans,William P. Gilks,Javier Fernandez de Simon,Marcel P. van der Brug,Adolfo López de Munain,Silvia Aparicio,Angel Martı́nez Gil,Naheed L. Khan,Janel O. Johnson,Javier Ruiz Martínez,David Nicholl,Itxaso Marti Carrera,Amets Saénz Peňa,Rohan de Silva,Andrew J. Lees,Jose Felix Marti-Masso,Jordi Pérez-Tur,Nicholas W. Wood,Andrew B. Singleton +20 more
TL;DR: The cloning of a novel gene that contains missense mutations segregating with PARK8-linked PD in five families from England and Spain is described and this protein is named dardarin, derived from the Basque word dardara, meaning tremor, because of the tremor observed in PD.
Journal ArticleDOI
Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells
Sandra Atienzar-Aroca,Miguel Flores-Bellver,Miguel Flores-Bellver,Gemma Serrano-Heras,Natalia Martínez-Gil,Jorge M. Barcia,Silvia Aparicio,Daniel Pérez-Cremades,José Manuel García-Verdugo,Manuel Díaz-Llopis,Francisco J. Romero,Javier Sancho-Pelluz +11 more
TL;DR: Results showed that stressed RPE cells released a higher amount of exosomes than controls, with a higher expression of V EGFR in the membrane, and enclosed an extra cargo of VEGFR mRNA.
Journal ArticleDOI
Epigenetic Study in Parkinson’s Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain
TL;DR: After analysing promoter regions of five PD-related genes in three brain regions by pyrosequencing, some differences in DNA methylation levels (hypo and hypermethylation) in substantia nigra in some CpG dinucleotides could alter their expression.