Journal ArticleDOI
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
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TLDR
It is proposed that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms.Abstract:
Sleep and circadian rhythm disruption are frequently observed in patients with psychiatric disorders and neurodegenerative disease. The abnormal sleep that is experienced by these patients is largely assumed to be the product of medication or some other influence that is not well defined. However, normal brain function and the generation of sleep are linked by common neurotransmitter systems and regulatory pathways. Disruption of sleep alters sleep-wake timing, destabilizes physiology and promotes a range of pathologies (from cognitive to metabolic defects) that are rarely considered to be associated with abnormal sleep. We propose that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms. The stabilization of sleep may be a means by which to reduce the symptoms of--and permit early intervention of--psychiatric and neurodegenerative disease.read more
Citations
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Circadian typology: a comprehensive review.
Ana Adan,Simon Archer,Maria Paz Loayza Hidalgo,Lee Di Milia,Vincenzo Natale,Christoph Randler +5 more
TL;DR: This review of the psychometric properties and validity of CT measures as well as individual, environmental and genetic factors that influence the circadian typology provides a state of the art discussion to allow professionals to integrate chronobiological aspects of human behavior into their daily practice.
Journal ArticleDOI
More green space is linked to less stress in deprived communities: Evidence from salivary cortisol patterns
Catharine Ward Thompson,Jennifer Roe,Peter Aspinall,Richard Mitchell,Angela Clow,David Miller +5 more
TL;DR: In this paper, the results of an exploratory study (n = 25) to establish whether salivary cortisol can act as a biomarker for variation in stress levels which may be associated with varying levels of exposure to green spaces, and whether recruitment and adherence to the required, unsupervised, salive cortisol sampling protocol within the domestic setting could be achieved in a highly deprived urban population.
Journal ArticleDOI
DeepSleepNet: A Model for Automatic Sleep Stage Scoring Based on Raw Single-Channel EEG
TL;DR: This paper proposes a deep learning model, named DeepSleepNet, for automatic sleep stage scoring based on raw single-channel EEG, and utilizes convolutional neural networks to extract time-invariant features, and bidirectional-long short-term memory to learn transition rules among sleep stages automatically from EEG epochs.
Journal ArticleDOI
The sleep-deprived human brain
Adam J. Krause,Eti Ben Simon,Bryce A. Mander,Stephanie Greer,Jared M. Saletin,Andrea N. Goldstein-Piekarski,Matthew P. Walker,Matthew P. Walker +7 more
TL;DR: The consequences of sleep deprivation on attention and working memory, positive and negative emotion, and hippocampal learning are reviewed, and how this evidence informs mechanistic understanding of the known changes in cognition and emotion associated with SD is explored.
References
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Journal ArticleDOI
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
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Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night
David F. Dinges,Frances M. Pack,Katherine M Williams,Kelly A. Gillen,John W. Powell,Geoffrey E. Ott,Caitlin Aptowicz,Allan I. Pack +7 more
TL;DR: It is suggested that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction.
Book
An Essay on the Shaking Palsy
TL;DR: In this article, the authors present a conciliatory explanation for the present publication, in which, it is acknowledged, that mere conjecture takes the place of experiment; and, that analogy is the substitute for anatomical examination, the only sure foundation for pathological knowledge.
Journal ArticleDOI
Molecular components of the mammalian circadian clock
TL;DR: The general mechanisms of the circadian clockwork are reviewed, recent findings that elucidate tissue-specific expression patterns of the clock genes are described and the importance of circadian regulation in peripheral tissues for an organism's overall well-being is addressed.