S
Silvia Vega-Rubin-de-Celis
Researcher at University of Texas Southwestern Medical Center
Publications - 19
Citations - 1685
Silvia Vega-Rubin-de-Celis is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 9, co-authored 13 publications receiving 1369 citations. Previous affiliations of Silvia Vega-Rubin-de-Celis include German Cancer Research Center & University of Texas at Dallas.
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Journal ArticleDOI
BAP1 loss defines a new class of renal cell carcinoma
Samuel Peña-Llopis,Silvia Vega-Rubin-de-Celis,Silvia Vega-Rubin-de-Celis,Arnold Liao,Nan Leng,Andrea Pavia-Jimenez,Andrea Pavia-Jimenez,Shanshan Wang,Shanshan Wang,Toshinari Yamasaki,Toshinari Yamasaki,Leah Zhrebker,Leah Zhrebker,Sharanya Sivanand,Sharanya Sivanand,Patrick Spence,Patrick Spence,Lisa N. Kinch,Tina Hambuch,Suneer Jain,Yair Lotan,Vitaly Margulis,Arthur I. Sagalowsky,Pia Banerji Summerour,Wareef Kabbani,S. W Wendy Wong,Nick V. Grishin,Marc Laurent,Xian Jin Xie,Christian D. Haudenschild,Mark T. Ross,David R. Bentley,Payal Kapur,James Brugarolas +33 more
TL;DR: The results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.
Journal ArticleDOI
Regulation of TFEB and V‐ATPases by mTORC1
Samuel Peña-Llopis,Silvia Vega-Rubin-de-Celis,Jacob C. Schwartz,Nicholas C. Wolff,Tram Anh T. Tran,Lihua Zou,Xian Jin Xie,David R. Corey,James Brugarolas +8 more
TL;DR: A regulatory network linking an oncogenic transcription factor that is a master regulator of lysosomal biogenesis, TFEB, to mTORC1 and endocytosis is uncovered.
Journal ArticleDOI
Multistep regulation of TFEB by MTORC1
TL;DR: It is reported that endogenous TFEB is phosphorylated at S122 in an MTORC1-dependent manner, that S122 isosphorylated in vitro by recombinant MTOR, and that S 122 is important for TFEb regulation by MTORc1.
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Increased autophagy blocks HER2-mediated breast tumorigenesis
Silvia Vega-Rubin-de-Celis,Zhongju Zou,Álvaro F. Fernández,Bo Ci,Min Kim,Guanghua Xiao,Yang Xie,Beth Levine +7 more
TL;DR: It is shown that a mutation in Becn1 that increases basal autophagy prevents HER2-mediated tumorigenesis in mice and prevents HER1-mediated inhibition of autophage in cultured cells, and that strategies to block HER2/Beclin 1 binding and/or increase autophile may represent a new therapeutic approach for Her2-positive breast cancers.
Journal ArticleDOI
Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Nicholas C. Wolff,Silvia Vega-Rubin-de-Celis,Xian Jin Xie,Diego H. Castrillon,Wareef Kabbani,James Brugarolas +5 more
TL;DR: It is shown that Redd1 induction by hypoxia is tissue dependent and thatHypoxia signals are relayed to mTORC1 through different pathways in a tissue-specific manner, illustrating a heretofore unappreciated topological complexity in mTORc1 regulation.