Z
Zhongju Zou
Researcher at University of Texas Southwestern Medical Center
Publications - 31
Citations - 4720
Zhongju Zou is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Autophagy & BECN1. The author has an hindex of 16, co-authored 27 publications receiving 3897 citations. Previous affiliations of Zhongju Zou include Howard Hughes Medical Institute.
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Journal ArticleDOI
Identification of a candidate therapeutic autophagy-inducing peptide
Sanae Shoji-Kawata,Rhea Sumpter,Matthew J Leveno,Grant R. Campbell,Grant R. Campbell,Zhongju Zou,Zhongju Zou,Lisa N. Kinch,Lisa N. Kinch,Angela D. Wilkins,Qihua Sun,Kathrin Pallauf,Donna A. MacDuff,Carlos Huerta,Carlos Huerta,Herbert W. Virgin,J. Bernd Helms,Ruud Eerland,Sharon A. Tooze,Ramnik J. Xavier,Ramnik J. Xavier,Deborah J. Lenschow,Ai Yamamoto,David S. King,Olivier Lichtarge,Nick V. Grishin,Stephen A. Spector,Stephen A. Spector,Dora V. Kaloyanova,Beth Levine +29 more
TL;DR: Through the characterization of a domain of beclin 1 that interacts with HIV-1 Nef, an autophagy-inducing peptide is developed that has potential efficacy in the treatment of human diseases.
Journal ArticleDOI
Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
Xueping Qu,Zhongju Zou,Qihua Sun,Katherine Luby-Phelps,Pengfei Cheng,Robert N Hogan,Christopher J. Gilpin,Beth Levine +7 more
TL;DR: It is concluded that autophagy contributes to dead-cell clearance during PCD by a mechanism that likely involves the generation of energy-dependent engulfment signals.
Journal ArticleDOI
Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
Richard C. Wang,Yongjie Wei,Z. H. An,Zhongju Zou,Guanghua Xiao,Govind Bhagat,Michael A. White,Julia Reichelt,Beth Levine +8 more
TL;DR: It is shown that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kinase Akt, and Akt-mediated phosphorylation of BeClin 1 functions in Autophagy inhibition, oncogenesis, and the formation of an autophile-inhibitory BeclIn 1/14-3-3/vimentin intermediate filament complex.
Journal ArticleDOI
Autophagy protects against Sindbis virus infection of the central nervous system.
TL;DR: A function for autophagy in mammalian antiviral defense is suggested: a cell-autonomous mechanism in which p62 adaptor-mediated autophagic viral protein clearance promotes cell survival.
Journal ArticleDOI
EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance
Yongjie Wei,Zhongju Zou,Nils Becker,Matthew E. Anderson,Rhea Sumpter,Guanghua Xiao,Lisa N. Kinch,Prasad Koduru,Christhunesa S. Christudass,Robert W. Veltri,Nick V. Grishin,Michael Peyton,John D. Minna,Govind Bhagat,Beth Levine +14 more
TL;DR: The molecular basis by which the epidermal growth factor receptor (EGFR) tyrosine kinase regulates autophagy is defined, which may contribute to tumor progression and chemoresistance.