Arnold Liao

TL;DR: An approach that generates several billion bases of accurate nucleotide sequence per experiment at low cost is reported, effective for accurate, rapid and economical whole-genome re-sequencing and many other biomedical applications.

TL;DR: The results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.

TL;DR: Integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches, providing a comprehensive view of how structural variations affect critical regulators in metastatic prostate cancer.

TL;DR: An ultrafast DNA sequence aligner (Isaac Genome Alignment Software) that takes advantage of high-memory hardware and variant caller and is demonstrated to be four to five times faster than BWA + GATK on equivalent hardware.

TL;DR: This study identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype and shows that differential methylation during progression preferentially occurs at somatic mutational hotspots and putative regulatory regions.