V
Vitaly Margulis
Researcher at University of Texas Southwestern Medical Center
Publications - 456
Citations - 14800
Vitaly Margulis is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Renal cell carcinoma & Medicine. The author has an hindex of 58, co-authored 394 publications receiving 12259 citations. Previous affiliations of Vitaly Margulis include University of California, Berkeley & I.M. Sechenov First Moscow State Medical University.
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Journal ArticleDOI
Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration
Vitaly Margulis,Shahrokh F. Shariat,Surena F. Matin,Ashish M. Kamat,Richard Zigeuner,Eiji Kikuchi,Yair Lotan,Alon Z. Weizer,Jay D. Raman,Christopher G. Wood +9 more
TL;DR: In this article, a large series of patients treated with radical nephroureterectomy for urothelial carcinoma were studied, and variables associated with poor prognosis were identified.
Journal ArticleDOI
BAP1 loss defines a new class of renal cell carcinoma
Samuel Peña-Llopis,Silvia Vega-Rubin-de-Celis,Silvia Vega-Rubin-de-Celis,Arnold Liao,Nan Leng,Andrea Pavia-Jimenez,Andrea Pavia-Jimenez,Shanshan Wang,Shanshan Wang,Toshinari Yamasaki,Toshinari Yamasaki,Leah Zhrebker,Leah Zhrebker,Sharanya Sivanand,Sharanya Sivanand,Patrick Spence,Patrick Spence,Lisa N. Kinch,Tina Hambuch,Suneer Jain,Yair Lotan,Vitaly Margulis,Arthur I. Sagalowsky,Pia Banerji Summerour,Wareef Kabbani,S. W Wendy Wong,Nick V. Grishin,Marc Laurent,Xian Jin Xie,Christian D. Haudenschild,Mark T. Ross,David R. Bentley,Payal Kapur,James Brugarolas +33 more
TL;DR: The results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.
Journal ArticleDOI
Prognostic factors in upper urinary tract urothelial carcinomas: a comprehensive review of the current literature.
Giovanni Lughezzani,Maximilian Burger,Vitaly Margulis,Surena F. Matin,Giacomo Novara,Morgan Rouprêt,Shahrokh F. Shariat,Christopher G. Wood,Richard Zigeuner +8 more
TL;DR: An overview of the currently available prognostic factors for UTUC, focusing on clinical and pathologic characteristics, as well as on molecular markers, is provided.
Journal ArticleDOI
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.
Steffen Durinck,Eric Stawiski,Andrea Pavia-Jimenez,Zora Modrusan,Payal Kapur,Bijay S. Jaiswal,Na Zhang,Vanina Toffessi-Tcheuyap,Thong T. Nguyen,Kanika Bajaj Pahuja,Ying Jiun Chen,Sadia Saleem,Subhra Chaudhuri,Sherry Heldens,Marlena Jackson,Samuel Peña-Llopis,Joseph Guillory,Karen Toy,Connie Ha,Corissa J. Harris,Eboni Holloman,Haley Hill,Jeremy Stinson,Celina Sanchez Rivers,Vasantharajan Janakiraman,Weiru Wang,Lisa N. Kinch,Lisa N. Kinch,Nick V. Grishin,Peter M. Haverty,Bernard Chow,Julian S. Gehring,Jens Reeder,Gregoire Pau,Thomas D. Wu,Vitaly Margulis,Yair Lotan,Arthur I. Sagalowsky,Ivan Pedrosa,Frederic J. de Sauvage,James Brugarolas,Somasekar Seshagiri +41 more
TL;DR: Gene expression analysis identified a five-gene set that enabled the molecular classification of chRCC, renal oncocytoma and pRCC and observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, suggesting a potential therapeutic role for BIRC 7 inhibitors.
Journal ArticleDOI
Lymphovascular Invasion Predicts Clinical Outcomes in Patients With Node-Negative Upper Tract Urothelial Carcinoma
Eiji Kikuchi,Vitaly Margulis,P.I. Karakiewicz,Marco Roscigno,Shuji Mikami,Yair Lotan,Mesut Remzi,Christian Bolenz,Cord Langner,Alon Weizer,Francesco Montorsi,Karim Bensalah,Theresa M. Koppie,Mario I. Fernández,Jay D. Raman,Wassim Kassouf,Christopher G. Wood,Nazareno Suardi,Mototsugu Oya,Shahrokh F. Shariat +19 more
TL;DR: Assessment of LVI may help identify patients who could benefit from multimodal therapy after RNU, and was an independent predictor of clinical outcomes in nonmetastatic patients who underwent RNU for UTUC.