N
Nan Leng
Researcher at Illumina
Publications - 10
Citations - 1036
Nan Leng is an academic researcher from Illumina. The author has contributed to research in topics: Diaphorina citri & Exome. The author has an hindex of 7, co-authored 9 publications receiving 888 citations. Previous affiliations of Nan Leng include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
BAP1 loss defines a new class of renal cell carcinoma
Samuel Peña-Llopis,Silvia Vega-Rubin-de-Celis,Silvia Vega-Rubin-de-Celis,Arnold Liao,Nan Leng,Andrea Pavia-Jimenez,Andrea Pavia-Jimenez,Shanshan Wang,Shanshan Wang,Toshinari Yamasaki,Toshinari Yamasaki,Leah Zhrebker,Leah Zhrebker,Sharanya Sivanand,Sharanya Sivanand,Patrick Spence,Patrick Spence,Lisa N. Kinch,Tina Hambuch,Suneer Jain,Yair Lotan,Vitaly Margulis,Arthur I. Sagalowsky,Pia Banerji Summerour,Wareef Kabbani,S. W Wendy Wong,Nick V. Grishin,Marc Laurent,Xian Jin Xie,Christian D. Haudenschild,Mark T. Ross,David R. Bentley,Payal Kapur,James Brugarolas +33 more
TL;DR: The results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.
Journal ArticleDOI
Improved annotation of the insect vector of citrus greening disease: biocuration by a diverse genomics community
Surya Saha,Prashant S. Hosmani,Krystal Villalobos-Ayala,Sherry Miller,Teresa D. Shippy,Mirella Flores,Andrew J. Rosendale,Chris Cordola,Tracey Bell,Hannah Mann,Gabe DeAvila,Daniel DeAvila,Zachary W. Q. Moore,Kyle Buller,Kathryn Ciolkevich,Samantha Nandyal,Robert Mahoney,Joshua Von Voorhis,Megan E. Dunlevy,David W. Farrow,David Hunter,Taylar Morgan,Kayla Shore,Victoria Guzman,Allison Izsak,Danielle E. Dixon,Danielle E. Dixon,Andrew G. Cridge,Liliana M. Cano,Xiaolong Cao,Haobo Jiang,Nan Leng,Shannon L. Johnson,Brandi L. Cantarel,Stephen Richards,Stephen Richards,Adam C. English,Adam C. English,Robert G. Shatters,Christopher P. Childers,Mei-Ju May Chen,Wayne B. Hunter,Michelle Cilia,Lukas A Mueller,Lukas A Mueller,Monica Munoz-Torres,David R. Nelson,Monica F. Poelchau,Joshua B. Benoit,Helen Wiersma-Koch,Tom D’Elia,Susan J Brown +51 more
TL;DR: To identify and improve gene models as potential targets for pest control, a community effort manually curated several gene families with a focus on genes that have key functional roles in D. citri biology and CLas interactions.
Journal ArticleDOI
Characterization of the Asian Citrus Psyllid Transcriptome.
Justin T. Reese,Matthew K. Christenson,Nan Leng,Surya Saha,Brandi L. Cantarel,Magdalen Lindeberg,Cecilia Tamborindeguy,Justin MacCarthy,Daniel G. Weaver,Andrew J. Trease,Steven V. Ready,Vincent M. Davis,Courtney McCormick,Christian D. Haudenschild,Shunsheng Han,Shannon L. Johnson,Kent S. Shelby,Hong Huang,Blake Bextine,Robert G. Shatters,David G. Hall,Paul H. Davis,Wayne B. Hunter +22 more
TL;DR: The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae) is a vector for the causative agents of Huanglongbing, which threatens citrus production worldwide and the first D. citri transcriptomes are reported and discussed.
Journal ArticleDOI
Achieving high-sensitivity for clinical applications using augmented exome sequencing
Anil Patwardhan,Jason Harris,Nan Leng,Gabor Bartha,Deanna M. Church,Shujun Luo,Christian Haudenschild,Mark Pratt,Justin M. Zook,Marc L. Salit,Jeanie Tirch,Massimo Morra,Stephen Chervitz,Ming Li,Michael J. Clark,Sarah Garcia,Gemma Chandratillake,Scott Kirk,Euan A. Ashley,Michael Snyder,Russ B. Altman,Carlos Bustamante,Atul J. Butte,John West,Richard Chen +24 more
TL;DR: In clinical applications where comprehensive coverage of medically interpretable areas of the genome requires higher localized sequencing depth, an augmented exome approach offers both cost and performance advantages over other sequencing-based tests.
Journal ArticleDOI
Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing.
Lorelei D. Shoemaker,Michael J. Clark,Anil Patwardhan,Gemma Chandratillake,Sarah Garcia,Rong Chen,Alexander A. Morgan,Nan Leng,Scott Kirk,Richard Chen,Douglas J. Cook,Michael Snyder,Gary K. Steinberg +12 more
TL;DR: Findings further support the East Asian origins of the RNF213 (p.R4810K) variant and more fully describe the genetic landscape of multiethnic MMD, revealing novel, alternative candidate variants and genes that may be important in MMD etiology and diagnosis.