S
Simon A. Broadley
Researcher at Griffith University
Publications - 10
Citations - 609
Simon A. Broadley is an academic researcher from Griffith University. The author has contributed to research in topics: Genome & Gene expression. The author has an hindex of 7, co-authored 10 publications receiving 575 citations.
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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Melanie Bahlo,David R. Booth,Simon A. Broadley,Matthew A. Brown,Matthew A. Brown,Simon J. Foote,Lyn R. Griffiths,Trevor J. Kilpatrick,Trevor J. Kilpatrick,Jeanette Lechner-Scott,Pablo Moscato,Victoria M. Perreau,Justin P. Rubio,Rodney J. Scott,Rodney J. Scott,Jim Stankovich,Graeme J. Stewart,Bruce V. Taylor,James S. Wiley,Glynnis Clarke,Mathew B Cox,Peter A. Csurhes,Patrick Danoy,Karen E. Drysdale,Judith Field,Judith M. Greer,Preethi Guru,Johanna Hadler,Brendan J. McMorran,Cathy J Jensen,Laura J. Johnson,Ruth McCallum,Marilyn E. Merriman,Tony R. Merriman,Karen Pryce,Lotfi Tajouri,Ella J Wilkins,Brian L. Browning,Sharon R. Browning,D. I. Perera,Simon Broadley,Helmut Butzkueven,Helmut Butzkueven,William M. Carroll,Caron Chapman,Allan G. Kermode,Mark Marriott,Deborah F. Mason,Robert Heard,Michael P. Pender,Michael P. Pender,Mark Slee,Niall Tubridy,Ernest Willoughby +53 more
TL;DR: To identify multiple sclerosis (MS) susceptibility loci, a genome-wide association study in 1,618 cases and used shared data for 3,413 controls and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15.
A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis | NOVA. The University of Newcastle's Digital Repository
Carlos Riveros,Drew Mellor,Stephen Vucic,Graeme J. Stewart,David W. Williams,R. J. Scott,Jeannette Lechner-Scott,David R. Booth,Pablo Moscato,Kaushal S. Gandhi,Fiona C. McKay,Mathew B Cox,Regina Berretta,S. Yahya Vaezpour,Mario Inostroza-Ponta,Simon A. Broadley,Robert Heard +16 more
TL;DR: A network of transcription factors that potentially dysregulate several genes in MS or one or more of its disease subtypes is uncovered, including those involved in early T-lymphocyte specification and commitment as well as in oligodendrocyte dedifferentiation and development.
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy | NOVA. The University of Newcastle's Digital Repository
Simon A. Broadley,Michael H. Barnett,Mark Marriott,Deborah F. Mason,John Parratt,Stephen W. Reddel,Cameron Shaw,Mark Slee,Judith M. Spies,Bruce V. Taylor,W.M. Carroll,Trevor J. Kilpatrick,Mike Boggild,John King,Pamela A. McCombe,John D. Pollard,Ernest Willoughby,Bruce J. Brew,Helmut Butzkueven,Robert Heard,Suzanne Hodgkinson,Allan G. Kermode,Jeannette Lechner-Scott,Richard A. L. Macdonell +23 more
TL;DR: The effectiveness of β-interferon in the treatment of different stages and the different disease courses of MS is critically reviewed with the conclusion that the absolute level of response in term of annualised relapse rates and MRI activity are similar, but are disappointing in terms of sustained disability progression for progressive forms of the disease as mentioned in this paper.
Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season | NOVA. The University of Newcastle's Digital Repository
Grant P Parnell,Prudence N. Gatt,Christopher Liddle,Mark Slee,Steve Vucic,Graeme J. Stewart,David R. Booth,Fiona C. McKay,Stephen D. Schibeci,Malgorzata Krupa,Joseph E. Powell,Peter M. Visscher,Grant W. Montgomery,Jeannette Lechner-Scott,Simon A. Broadley +14 more
TL;DR: Data support investigation of RPS6 as a potential therapeutic target and candidate biomarker for measuring clinical response to IFNB and other MS therapies, and of MS disease heterogeneity.
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 3 Treatment practicalities and recommendations | NOVA. The University of Newcastle's Digital Repository
Simon A. Broadley,Michael H. Barnett,Mark Marriott,Deborah F. Mason,John Parratt,Stephen W. Reddel,Cameron Shaw,Mark Slee,Judith M. Spies,Bruce V. Taylor,W.M. Carroll,Trevor J. Kilpatrick,Mike Boggild,John King,Pamela A. McCombe,John D. Pollard,Ernest Willoughby,Bruce J. Brew,Helmut Butzkueven,Robert Heard,Suzanne Hodgkinson,Allan G. Kermode,Jeannette Lechner-Scott,Richard A. L. Macdonell +23 more
TL;DR: In this paper, the authors reviewed the practical day-to-day management issues that are likely to influence individual treatment decisions and made specific recommendations with regards to the treatment of MS.