M
Mark Slee
Researcher at Flinders University
Publications - 110
Citations - 5891
Mark Slee is an academic researcher from Flinders University. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 34, co-authored 91 publications receiving 4656 citations. Previous affiliations of Mark Slee include Katholieke Universiteit Leuven & John Radcliffe Hospital.
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Journal ArticleDOI
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley Beecham,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Dionysia K. Xifara,Mary F. Davis,Anu Kemppinen,Chris Cotsapas,Chris Cotsapas,Tejas S. Shah,Chris C. A. Spencer,David R. Booth,An Goris,Annette Bang Oturai,Janna Saarela,Bertrand Fontaine,Bernhard Hemmer,C. Martin,Frauke Zipp,Sandra D'Alfonso,Filippo Martinelli-Boneschi,Bruce V. Taylor,Hanne F. Harbo,Ingrid Kockum,Jan Hillert,Tomas Olsson,Maria Ban,Jorge R. Oksenberg,Rogier Q. Hintzen,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Cristina Agliardi,Lars Alfredsson,Mehdi Alizadeh,Carl A. Anderson,Robert Andrews,Helle Bach Søndergaard,Amie Baker,Gavin Band,Sergio E. Baranzini,Nadia Barizzone,Jeffrey C. Barrett,Céline Bellenguez,Laura Bergamaschi,Luisa Bernardinelli,Achim Berthele,Viola Biberacher,Thomas M.C. Binder,Hannah Blackburn,Izaura Lima Bomfim,Paola Brambilla,Simon Broadley,Bruno Brochet,Lou Brundin,Dorothea Buck,Helmut Butzkueven,Helmut Butzkueven,Stacy J. Caillier,William Camu,Wassila Carpentier,Paola Cavalla,Elisabeth Gulowsen Celius,Irene Coman,Giancarlo Comi,Lucia Corrado,Leentje Cosemans,Isabelle Cournu-Rebeix,Bruce A.C. Cree,Daniele Cusi,Vincent Damotte,Gilles Defer,Silvia Delgado,Panos Deloukas,Alessia Di Sapio,Alexander T. Dilthey,Peter Donnelly,Bénédicte Dubois,Martin Duddy,Sarah Edkins,Irina Elovaara,Federica Esposito,Nikos Evangelou,Barnaby Fiddes,Judith Field,Andre Franke,Colin Freeman,Irene Y. Frohlich,Daniela Galimberti,Christian Gieger,Pierre-Antoine Gourraud,Christiane Graetz,Andrew Graham,Verena Grummel,Clara Guaschino,Athena Hadjixenofontos,Hakon Hakonarson,Christopher Halfpenny,Gillian L Hall,Per Hall,Anders Hamsten,James Harley,Timothy Harrower,Clive Hawkins,Garrett Hellenthal,Charles Hillier,Jeremy Hobart,M.-M. Hoshi,Sarah E. Hunt,Maja Jagodic,Ilijas Jelcic,Ilijas Jelcic,Angela Jochim,B. E. Kendall,Allan G. Kermode,Allan G. Kermode,Trevor J. Kilpatrick,Keijo Koivisto,Ioanna Konidari,Thomas Korn,Helena C. Kronsbein,Cordelia Langford,Malin Larsson,Mark Lathrop,Mark Lathrop,Christine Lebrun-Frenay,Jeannette Lechner-Scott,Michelle Lee,Maurizio Leone,Virpi Leppa,Giuseppe Liberatore,Benedicte A. Lie,Christina M. Lill,Christina M. Lill,Magdalena Lindén,Jenny Link,Felix Luessi,Jan Lycke,Fabio Macciardi,Fabio Macciardi,Satu Männistö,Clara P. Manrique,Roland Martin,Roland Martin,Vittorio Martinelli,Deborah F. Mason,Gordon Mazibrada,Cristin McCabe,Inger Lise Mero,Julia Y Mescheriakova,Loukas Moutsianas,Kjell-Morten Myhr,Guy Nagels,Richard Nicholas,Petra Nilsson,Fredrik Piehl,Matti Pirinen,Siân Price,Hong Quach,Mauri Reunanen,Wim Robberecht,Neil Robertson,Mariaemma Rodegher,David Rog,Marco Salvetti,Nathalie Schnetz-Boutaud,Finn Sellebjerg,Rebecca C. Selter,Catherine Schaefer,Sandip Shaunak,Ling Shen,Simon Shields,Volker Siffrin,Mark Slee,Per Soelberg Sørensen,Melissa Sorosina,Mireia Sospedra,Mireia Sospedra,Anne Spurkland,Amy Strange,Emilie Sundqvist,Vincent Thijs,J W Thorpe,Anna Ticca,Pentti J. Tienari,Cornelia M. van Duijn,Elizabeth Visser,Steve Vucic,Helga Westerlind,James S. Wiley,Alastair Wilkins,James F. Wilson,Juliane Winkelmann,John Zajicek,Eva Zindler,Jonathan L. Haines,Margaret A. Pericak-Vance,Adrian J. Ivinson,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Alastair Compston,Gil McVean,Philip L. De Jager,Philip L. De Jager,Stephen Sawcer,Jacob L. McCauley +206 more
TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Journal ArticleDOI
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Melanie Bahlo,David R. Booth,Simon A. Broadley,Matthew A. Brown,Matthew A. Brown,Simon J. Foote,Lyn R. Griffiths,Trevor J. Kilpatrick,Trevor J. Kilpatrick,Jeanette Lechner-Scott,Pablo Moscato,Victoria M. Perreau,Justin P. Rubio,Rodney J. Scott,Rodney J. Scott,Jim Stankovich,Graeme J. Stewart,Bruce V. Taylor,James S. Wiley,Glynnis Clarke,Mathew B Cox,Peter A. Csurhes,Patrick Danoy,Karen E. Drysdale,Judith Field,Judith M. Greer,Preethi Guru,Johanna Hadler,Brendan J. McMorran,Cathy J Jensen,Laura J. Johnson,Ruth McCallum,Marilyn E. Merriman,Tony R. Merriman,Karen Pryce,Lotfi Tajouri,Ella J Wilkins,Brian L. Browning,Sharon R. Browning,D. I. Perera,Simon Broadley,Helmut Butzkueven,Helmut Butzkueven,William M. Carroll,Caron Chapman,Allan G. Kermode,Mark Marriott,Deborah F. Mason,Robert Heard,Michael P. Pender,Michael P. Pender,Mark Slee,Niall Tubridy,Ernest Willoughby +53 more
TL;DR: To identify multiple sclerosis (MS) susceptibility loci, a genome-wide association study in 1,618 cases and used shared data for 3,413 controls and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15.
Journal ArticleDOI
Association of Initial Disease-Modifying Therapy with Later Conversion to Secondary Progressive Multiple Sclerosis
J William L Brown,J William L Brown,J William L Brown,Alasdair Coles,Dana Horakova,Eva Havrdova,Guillermo Izquierdo,Alexandre Prat,Marc Girard,Pierre Duquette,Maria Trojano,Alessandra Lugaresi,Roberto Bergamaschi,Pierre Grammond,Raed Alroughani,Raymond Hupperts,Pamela A. McCombe,Vincent Van Pesch,Patrizia Sola,Diana Ferraro,Francois Grand'Maison,Murat Terzi,Jeannette Lechner-Scott,Schlomo Flechter,Mark Slee,Vahid Shaygannejad,Eugenio Pucci,Franco Granella,Vilija Jokubaitis,Vilija Jokubaitis,Mark Willis,Claire M Rice,Neil J Scolding,Alastair Wilkins,Owen R Pearson,Tjalf Ziemssen,Michael Hutchinson,Katharine Harding,Joanne L. Jones,Christopher McGuigan,Helmut Butzkueven,Helmut Butzkueven,Helmut Butzkueven,Tomas Kalincik,Tomas Kalincik,Neil Robertson +45 more
TL;DR: The probability of conversion was lower when glatiramer acetate or interferon beta was started within 5 years of disease onset vs later, and initial treatment with fingolimod, alemtuzumab, or natalizumab was associated with a lower risk of conversion.
Journal ArticleDOI
Defining secondary progressive multiple sclerosis.
Johannes Lorscheider,Johannes Lorscheider,Katherine Buzzard,Katherine Buzzard,Katherine Buzzard,Vilija Jokubaitis,Vilija Jokubaitis,Tim Spelman,Eva Havrdova,Dana Horakova,Maria Trojano,Guillermo Izquierdo,Marc Girard,Pierre Duquette,Alexandre Prat,Alessandra Lugaresi,Francois Grand'Maison,Pierre Grammond,Raymond Hupperts,Raed Alroughani,Patrizia Sola,Cavit Boz,Eugenio Pucci,Jeanette Lechner-Scott,Jeanette Lechner-Scott,Roberto Bergamaschi,Celia Oreja-Guevara,Gerardo Iuliano,Vincent Van Pesch,Franco Granella,Cristina Ramo-Tello,Daniele Spitaleri,Thor Petersen,Mark Slee,Freek Verheul,Radek Ampapa,Maria Pia Amato,Pamela A. McCombe,Steve Vucic,José Luis Sánchez Menoyo,Edgardo Cristiano,Michael Barnett,Suzanne Hodgkinson,Javier Olascoaga,Maria Laura Saladino,Orla Gray,Cameron Shaw,Fraser Moore,Helmut Butzkueven,Helmut Butzkueven,Helmut Butzkueven,Tomas Kalincik,Tomas Kalincik +52 more
TL;DR: In this article, the authors evaluated the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies, using MSBase, a large, prospectively acquired, global cohort study, and analyzed the accuracy of 576 data-derived onset definitions for SPM and compared these to a consensus opinion of three neurologists.
Journal ArticleDOI
Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis
Maria Trojano,Guglielmo Lucchese,Giusi Graziano,Bruce V. Taylor,Steve Simpson,Vito Lepore,Francois Grand'Maison,Pierre Duquette,Guillermo Izquierdo,Pierre Grammond,Maria Pia Amato,Roberto Bergamaschi,Giorgio Giuliani,Cavit Boz,Raymond Hupperts,Vincent Van Pesch,Jeannette Lechner-Scott,Edgardo Cristiano,Marcela Fiol,Celia Oreja-Guevara,Maria Laura Saladino,Freek Verheul,Mark Slee,Damiano Paolicelli,Carla Tortorella,Mariangela D'Onghia,Pietro Iaffaldano,Vita Direnzo,Helmut Butzkueven,Helmut Butzkueven,Helmut Butzkueven +30 more
TL;DR: A general sex ratio increase over time in RRMS is confirmed and a latitudinal gradient of this increase is demonstrated, adding useful information for planning case-control studies aimed to explore sex-related factors responsible for MS development.