K
Kristian Nygaard Mortensen
Researcher at University of Copenhagen
Publications - 13
Citations - 847
Kristian Nygaard Mortensen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Glymphatic system & Cerebrospinal fluid. The author has an hindex of 6, co-authored 9 publications receiving 424 citations. Previous affiliations of Kristian Nygaard Mortensen include Yale University.
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Journal ArticleDOI
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia
Lauren M. Hablitz,Hanna S. Vinitsky,Qian Sun,Frederik Filip Stæger,Björn Sigurdsson,Kristian Nygaard Mortensen,Tuomas Lilius,Tuomas Lilius +7 more
TL;DR: This is the first study to show that glymphatic influx correlates positively with cortical delta power in EEG recordings and negatively with beta power and heart rate.
Journal ArticleDOI
Cerebrospinal fluid influx drives acute ischemic tissue swelling
Humberto Mestre,Ting Du,Ting Du,Amanda M. Sweeney,Guojun Liu,Guojun Liu,Andrew J. Samson,Weiguo Peng,Kristian Nygaard Mortensen,Frederik Filip Stæger,Peter A. R. Bork,Peter A. R. Bork,Logan Bashford,Edna R Toro,Jeffrey Tithof,Douglas H. Kelley,John H. Thomas,Poul G. Hjorth,Erik A. Martens,Rupal I. Mehta,Orestes Solis,Pablo Blinder,David Kleinfeld,Hajime Hirase,Yuki Mori +24 more
TL;DR: It is found that within minutes of ischemic stroke, CSF flowed rapidly into brain tissue along perivascular spaces and the cerebral ventricles compared with regions deep in the brain that were far from large CSF reservoirs, and CSF was the earliest contributor of both fluid and ions.
Journal ArticleDOI
Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
Kristian Nygaard Mortensen,Simon Sanggaard,Simon Sanggaard,Humberto Mestre,Hedok Lee,Serhii Kostrikov,Anna L.R. Xavier,Albert Gjedde,Albert Gjedde,Helene Benveniste +9 more
TL;DR: The study demonstrates the suppression of glymphatic clearance in SHR rats and thus offers new insight into the coexistence of hypertension and concomitant vascular pathologies in Alzheimer's disease, as well as providing a new perspective on the importance for brain metabolite and fluid homeostasis of maintaining healthy blood vessels.
Journal ArticleDOI
The Minimal Energetic Requirement of Sustained Awareness after Brain Injury
Johan Stender,Johan Stender,Kristian Nygaard Mortensen,Aurore Thibaut,Sune Darkner,Steven Laureys,Albert Gjedde,Ron Kupers,Ron Kupers +8 more
TL;DR: The cerebral metabolic rate accounted for the current level, or imminent return, of awareness in 94% of the patient population, suggesting a global energetic threshold effect, associated with the reemergence of consciousness after brain injury.
Journal ArticleDOI
Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T
Hedok Lee,Kristian Nygaard Mortensen,Simon Sanggaard,Palle Koch,Hans Brunner,Bjørn Quistorff,Helene Benveniste +6 more
TL;DR: A quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast‐enhanced MRI (DCE‐MRI) is proposed and whole brain gadolinium concentration maps are derived.