S
Simona Foscarin
Researcher at University of Cambridge
Publications - 8
Citations - 329
Simona Foscarin is an academic researcher from University of Cambridge. The author has contributed to research in topics: Perineuronal net & Chondroitin sulfate. The author has an hindex of 5, co-authored 8 publications receiving 229 citations.
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Journal ArticleDOI
"GAG-ing with the neuron": The role of glycosaminoglycan patterning in the central nervous system.
Patrice D. Smith,Patrice D. Smith,Vivien Jane Coulson-Thomas,Simona Foscarin,Jessica C. F. Kwok,James W. Fawcett +5 more
TL;DR: The role of all the identified PG family members (CS, HS, HEP, DS, KS and HA) in normal CNS function and in the context of pathology are discussed.
Journal ArticleDOI
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.
TL;DR: It is suggested that the change in PNN GAG sulfation in aged brains renders the PNNs more inhibitory, which lead to a decrease in plasticity and adversely affect memory.
Journal ArticleDOI
Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
Animesh Alexander Raha,James Henderson,Simon R.W. Stott,Romina Vuono,Simona Foscarin,Robert P. Friedland,Shahid Zaman,Ruma Raha-Chowdhury +7 more
TL;DR: It is shown that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells, and is essential for neuroplasticity and myelination.
Journal ArticleDOI
Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.
Ruma Raha-Chowdhury,James Henderson,Animesh Alexander Raha,Simon R.W. Stott,Romina Vuono,Simona Foscarin,Liam R. Wilson,Tiina Annus,Robert Fincham,Kieren Allinson,Vinod Devalia,Robert P. Friedland,Anthony J. Holland,Shahid Zaman +13 more
TL;DR: Evidence is provided that peripheral TREM2 originating from erythromyeloid cells significantly determines AD neuropathology in DS subjects and understanding the molecular signaling pathways mediated by T REM2 may reveal novel therapeutic targets.
Journal ArticleDOI
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
Sujeong Yang,Sylvain Gigout,Angelo Molinaro,Yuko Naito-Matsui,Sam Hilton,Simona Foscarin,Bart Nieuwenhuis,Bart Nieuwenhuis,Chin Lik Tan,Joost Verhaagen,Tommaso Pizzorusso,Lisa M. Saksida,Timothy M. Bussey,Hiroshi Kitagawa,Jessica C. F. Kwok,James W. Fawcett +15 more
TL;DR: This article investigated whether manipulation of the chondroitin sulphate (CS) composition of perineuronal nets could restore neuroplasticity and alleviate memory deficits in aged mice.