S
Simon R.W. Stott
Researcher at University of Cambridge
Publications - 38
Citations - 1963
Simon R.W. Stott is an academic researcher from University of Cambridge. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 18, co-authored 34 publications receiving 1480 citations. Previous affiliations of Simon R.W. Stott include Lund University & National Institute for Medical Research.
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Journal ArticleDOI
Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells
Gioele La Manno,Gioele La Manno,Daniel Gyllborg,Simone Codeluppi,Simone Codeluppi,Kaneyasu Nishimura,Carmen Saltó,Amit Zeisel,Amit Zeisel,Lars E. Borm,Lars E. Borm,Simon R.W. Stott,Enrique M. Toledo,J. Carlos Villaescusa,J. Carlos Villaescusa,Peter Lönnerberg,Peter Lönnerberg,Jesper Ryge,Roger A. Barker,Ernest Arenas,Sten Linnarsson,Sten Linnarsson +21 more
TL;DR: Insight is provided into the molecular programs controlling human midbrain development and provides a foundation for the development of cell replacement therapies for Parkinson’s disease.
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Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
Jens M. Nygren,Karina Liuba,Martin Breitbach,Simon R.W. Stott,Lina Thorén,Wilhelm Roell,Caroline Geisen,Philipp Sasse,Deniz Kirik,Anders Björklund,Claus Nerlov,Claus Nerlov,Bernd K. Fleischmann,Stefan Jovinge,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +15 more
TL;DR: It is demonstrated that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.
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Neurogenin2 Directs Granule Neuroblast Production and Amplification while NeuroD1 Specifies Neuronal Fate during Hippocampal Neurogenesis
TL;DR: A critical role is demonstrated for Ngn2 and NeuroD1 in controlling neuronal commitment and hippocampal granule neuroblast formation, both during embryonic development and in post-natal hippocampalgranule neurogenesis.
Journal ArticleDOI
Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease
Simon R.W. Stott,Roger A. Barker +1 more
TL;DR: Observations of the neurodegenerative process in the 6‐OHDA mouse model can be applied to future studies looking at therapeutic interventions, and include changes in the expression of Aldh1a1 (aldehyde dehydrogenase 1 family, member A1) as the neuro degenerative process evolved.
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In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.
TL;DR: It is proposed that SSEA4 associated with CD133 can be used for both the positive selection and the enrichment of neural stem/progenitor cells from human embryonic forebrain.