V
Vittorio Sartorelli
Researcher at National Institutes of Health
Publications - 119
Citations - 15969
Vittorio Sartorelli is an academic researcher from National Institutes of Health. The author has contributed to research in topics: MyoD & Cellular differentiation. The author has an hindex of 60, co-authored 112 publications receiving 14441 citations. Previous affiliations of Vittorio Sartorelli include Stanford University & University of Southern California.
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Journal ArticleDOI
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
Marcella Fulco,Yana Cen,Po Zhao,Eric P. Hoffman,Michael W. McBurney,Anthony A. Sauve,Vittorio Sartorelli +6 more
TL;DR: These experiments reveal that AMPK, Nampt, and SIRT1 are the molecular components of a functional signaling pathway that allows skeletal muscle cells to sense and react to nutrient availability.
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The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
TL;DR: The findings suggest the existence of a two-step activation mechanism whereby removal of H3-K27 methylation, conferred by an active Ezh2-containing protein complex, followed by recruitment of positive transcriptional regulators at discrete genomic loci are required to promote muscle gene expression and cell differentiation.
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Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
Marcella Fulco,R. Louis Schiltz,Simona Iezzi,M. Todd King,Po Zhao,Yoshihiro Kashiwaya,Eric P. Hoffman,Richard L. Veech,Vittorio Sartorelli +8 more
TL;DR: Results indicate that Sir2 regulates muscle gene expression and differentiation by possibly functioning as a redox sensor in response to exercise, food intake, and starvation, Sir2 may sense modifications of the redox state and promptly modulate gene expression.
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twist is a potential oncogene that inhibits apoptosis
Roberta Maestro,Angelo Paolo Dei Tos,Yasuo Hamamori,Svetlana Krasnokutsky,Vittorio Sartorelli,Larry Kedes,Claudio Doglioni,David Beach,Gregory J. Hannon +8 more
TL;DR: Twin may play multiple roles in the formation of rhabdomyosarcomas, halting terminal differentiation, inhibiting apoptosis, and interfering with the p53 tumor-suppressor pathway.
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Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
Pier Lorenzo Puri,Pier Lorenzo Puri,Vittorio Sartorelli,Vittorio Sartorelli,Xiang Jiao Yang,Yasuo Hamamori,Vasily Ogryzko,Bruce H. Howard,Larry Kedes,Jean Y. J. Wang,Adolf Graessmann,Yoshihiro Nakatani,Massimo Levrero,Massimo Levrero +13 more
TL;DR: Results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program.