Pier Lorenzo Puri

TL;DR: This study is the first to demonstrate that induction of adult-like metabolism has a critical role in establishing an adult-onset disease model using patient-specific iPSCs, and revealed crucial pathogenic insights that metabolic derangement in adult- like metabolic milieu underlies ARVD/C pathologies, enabling us to propose novel disease-modifying therapeutic strategies.

TL;DR: Investigation of the role of two MAPKs, p38 and extracellular signal-regulated kinase (ERK), whose activities undergo significant changes during muscle differentiation finds p38 is rapidly activated in myocytes induced to differentiate and ERK shows a biphasic activation profile, with peaks of activity in undifferentiated myoblasts and postmitotic myotubes.

TL;DR: Results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program.

TL;DR: An unexpected function of differentiation-activated p38 is identified in converting external cues into chromatin modifications at discrete loci, by selectively targeting SWI-SNF to muscle-regulatory elements.

TL;DR: It is shown that Twist directly binds two independent HAT domains of acetyltransferases, p300 and p300/CBP-associated factor (PCAF), and directly regulates their HAT activities.