S
Simona Santangelo
Researcher at Sapienza University of Rome
Publications - 23
Citations - 1047
Simona Santangelo is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chronic lymphocytic leukemia & Leukemia. The author has an hindex of 12, co-authored 23 publications receiving 993 citations.
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Journal ArticleDOI
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.
Valerio Fulci,Sabina Chiaretti,Marina Goldoni,Gianluca Azzalin,Nicoletta Carucci,Simona Tavolaro,Leandro Castellano,Armando Magrelli,Franca Citarella,Monica Messina,Roberta Maggio,Nadia Peragine,Simona Santangelo,Francesca Romana Mauro,Pablo Landgraf,Thomas Tuschl,David B. Weir,Minchen Chien,James J. Russo,Jingyue Ju,Robert L. Sheridan,Chris Sander,Mihaela Zavolan,Anna Guarini,Robin Foà,Giuseppe Macino +25 more
TL;DR: The results of this study offer for the first time a comprehensive and quantitative profile of miRNA expression in CLL and their healthy counterpart, suggesting that miRNAs could play a primary role in the disease itself.
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BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Anna Guarini,Sabina Chiaretti,Simona Tavolaro,Roberta Maggio,Nadia Peragine,Franca Citarella,Maria Rosaria Ricciardi,Simona Santangelo,Marilisa Marinelli,Maria Stefania De Propris,Monica Messina,Francesca Romana Mauro,Ilaria Del Giudice,Robert Foa +13 more
TL;DR: A differential genotypic and functional response to BCR ligation between IgV(H) M and UM cases is operational in CLL, indicating that response to antigenic stimulation plays a pivotal role in disease progression.
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ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression
Anna Guarini,Marilisa Marinelli,Simona Tavolaro,Emanuele Bellacchio,Monia Magliozzi,Sabina Chiaretti,Maria Stefania De Propris,Nadia Peragine,Simona Santangelo,Francesca Paoloni,Mauro Nanni,Ilaria Del Giudice,Francesca Romana Mauro,Isabella Torrente,Robin Foà +14 more
TL;DR: Investigation of the role of ATM gene alterations, their biological consequences and their value in predicting disease progression led to a hypothesis that functional abnormalities are responsible for the unfavorable clinical course of patients carrying these point mutations.
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Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases
Ilaria Del Giudice,Sabina Chiaretti,Simona Tavolaro,Maria Stefania De Propris,Roberta Maggio,Francesca Mancini,Nadia Peragine,Simona Santangelo,Marilisa Marinelli,Francesca Romana Mauro,Anna Guarini,Robin Foà +11 more
TL;DR: Microarray analysis of CLL cells showed a distinctive genomic profile with an overrepresentation of BCR-related and ribosomal genes, regulators of signal transduction and transcription, which suggests that BCR signaling may play an important role in this scenario as the most significant feature of the leukemic clone in regression.
Journal ArticleDOI
Evaluation of TP53 mutations with the AmpliChip p53 research test in chronic lymphocytic leukemia: correlation with clinical outcome and gene expression profiling.
Sabina Chiaretti,Simona Tavolaro,Marilisa Marinelli,Monica Messina,Ilaria Del Giudice,Francesca Romana Mauro,Simona Santangelo,Alfonso Piciocchi,Nadia Peragine,Sim Truong,Nancy Patten,Emanuela M. Ghia,Isabella Torrente,Maria Stefania De Propris,Mauro Nanni,Jeffrey Lawrence,Anna Guarini,Robin Foà +17 more
TL;DR: A high percentage of TP53 mutations are found in CLL with unfavorable outcome and a significant association between TP53 aberrations and del(17p) was recorded, and specific gene expression profiles are recognized for TP53 alterations.