Roberta Maggio

TL;DR: The results of this study offer for the first time a comprehensive and quantitative profile of miRNA expression in CLL and their healthy counterpart, suggesting that miRNAs could play a primary role in the disease itself.

TL;DR: HaCaT cells, a long-lived, spontaneously immortalized human keratinocyte line which is able to differentiate in vitro, is investigated as a suitable model to follow the release of inflammatory and repair mediators in response to TNFα or IL-1β to highlight that Ca2+ concentration in the medium, cell density, and presence of serum influences at different levels therelease of proinflammatory mediators by HaCaT Cells.

TL;DR: A differential genotypic and functional response to BCR ligation between IgV(H) M and UM cases is operational in CLL, indicating that response to antigenic stimulation plays a pivotal role in disease progression.

TL;DR: Microarray analysis of CLL cells showed a distinctive genomic profile with an overrepresentation of BCR-related and ribosomal genes, regulators of signal transduction and transcription, which suggests that BCR signaling may play an important role in this scenario as the most significant feature of the leukemic clone in regression.

TL;DR: These findings document for the first time the possibility of expanding ex vivo cytotoxic effectors with autologous killing capacity from ALL patients in remission, and suggest a new potential immunotherapeutic strategy for the management of early disease recurrence or of residual disease.