S
Simona Tavolaro
Researcher at Sapienza University of Rome
Publications - 39
Citations - 2140
Simona Tavolaro is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Chronic lymphocytic leukemia & breakpoint cluster region. The author has an hindex of 18, co-authored 39 publications receiving 2020 citations. Previous affiliations of Simona Tavolaro include Policlinico Umberto I & Harvard University.
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Journal ArticleDOI
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.
Valerio Fulci,Sabina Chiaretti,Marina Goldoni,Gianluca Azzalin,Nicoletta Carucci,Simona Tavolaro,Leandro Castellano,Armando Magrelli,Franca Citarella,Monica Messina,Roberta Maggio,Nadia Peragine,Simona Santangelo,Francesca Romana Mauro,Pablo Landgraf,Thomas Tuschl,David B. Weir,Minchen Chien,James J. Russo,Jingyue Ju,Robert L. Sheridan,Chris Sander,Mihaela Zavolan,Anna Guarini,Robin Foà,Giuseppe Macino +25 more
TL;DR: The results of this study offer for the first time a comprehensive and quantitative profile of miRNA expression in CLL and their healthy counterpart, suggesting that miRNAs could play a primary role in the disease itself.
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Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
Elisabetta Flex,Valentina Petrangeli,Lorenzo Stella,Sabina Chiaretti,Tekla Hornakova,Laurent Knoops,Cristina Ariola,Valentina Fodale,Emmanuelle Clappier,Francesca Paoloni,Simone Martinelli,Alessandra Fragale,Massimo Sanchez,Simona Tavolaro,Monica Messina,Giovanni Cazzaniga,Andrea Camera,Giovanni Pizzolo,Assunta Tornesello,Marco Vignetti,Angela Battistini,Hélène Cavé,Bruce D. Gelb,Jean-Christophe Renauld,Andrea Biondi,Stefan N. Constantinescu,Robin Foà,Marco Tartaglia +27 more
TL;DR: It is reported that somatic mutations in JAK1 occur in individuals with acute lymphoblastic leukemia (ALL), and this kinase is pointed to as a target for the development of novel antileukemic drugs.
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NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL.
Ilaria Del Giudice,Davide Rossi,Sabina Chiaretti,Marilisa Marinelli,Simona Tavolaro,Sara Gabrielli,Luca Laurenti,Roberto Marasca,Silvia Rasi,Marco Fangazio,Anna Guarini,Gianluca Gaidano,Robin Foà +12 more
TL;DR: The overrepresentation of cell cycle/proliferation related genes of +12 CLL with Notch1 mutations suggests the biological contribution of NOTCH1 mutations to determine a poor outcome and refine the intermediate prognosis of + 12 CLL.
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BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Anna Guarini,Sabina Chiaretti,Simona Tavolaro,Roberta Maggio,Nadia Peragine,Franca Citarella,Maria Rosaria Ricciardi,Simona Santangelo,Marilisa Marinelli,Maria Stefania De Propris,Monica Messina,Francesca Romana Mauro,Ilaria Del Giudice,Robert Foa +13 more
TL;DR: A differential genotypic and functional response to BCR ligation between IgV(H) M and UM cases is operational in CLL, indicating that response to antigenic stimulation plays a pivotal role in disease progression.
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Chlorambucil plus rituximab with or without maintenance rituximab as first‐line treatment for elderly chronic lymphocytic leukemia patients
Robin Foà,Ilaria Del Giudice,Antonio Cuneo,Giovanni Del Poeta,Stefania Ciolli,Francesco Di Raimondo,Francesco Lauria,Emanuele Cencini,Gian Matteo Rigolin,Agostino Cortelezzi,Francesco Nobile,Vincenzo Callea,Maura Brugiatelli,Massimo Massaia,Stefano Molica,Livio Trentin,Rita Rizzi,Giorgina Specchia,Francesca Di Serio,Lorella Orsucci,Achille Ambrosetti,Marco Montillo,Pier Luigi Zinzani,Felicetto Ferrara,Fortunato Morabito,Maria Angela Mura,Silvia Soriani,Nadia Peragine,Simona Tavolaro,Silvia Bonina,Marilisa Marinelli,Maria Stefania De Propris,Irene Della Starza,Alfonso Piciocchi,Alessandra Alietti,Eva J. Runggaldier,Enrica Gamba,Francesca Romana Mauro,Sabina Chiaretti,Anna Guarini +39 more
TL;DR: R maintenance tended towards a better PFS than observation and was safe and most beneficial for patients in partial response and for unmutated IGHV cases.