Giuseppe Macino

TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.

TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.

TL;DR: The phenotypic reversion is characterized by a progressive release of the transcriptional inhibition and seems to correlate with a reduction of the number of the ectopic integrated sequences, which indicates that quelling appears to be monodirectional, as, once relieved, it cannot take place again, despite the continuing presence of some of theectopic sequences in the genome.

TL;DR: The cloning of qde-1, the first cellular component of the gene-silencing mechanism to be isolated, defines a new gene family conserved among different species including plants, animals and fungi, which is similar to an RNA-dependent RNA polymerase found in the tomato.

TL;DR: The hypothesis that miRNA expression broadly contributes to tissue specificity of mRNA expression in many human tissues is supported.