Simone Reu

TL;DR: It is postulate that an important driving force for progression of well-differentiated colorectal carcinomas is the specific environment, initiating two transient phenotypic transition processes by modulating intracellular β-catenin distribution in tumor cells.

TL;DR: The data indicate that carcinoma cells can be reproducibly scored in PD-L1 immunohistochemistry for pulmonary adenocarcinoma and squamous-cell carcinoma and might require specific standardization.

TL;DR: It is shown that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model.

TL;DR: Overall long-term survival of subjects with two disease-causing ABCA3 mutations was <20%.

TL;DR: Investigation of p16Ink4a expression and promoter methylation in BRAF-mutated serrated lesions of the colon provides evidence for oncogene-induced senescence in the serrated route to colorectal cancer with BRAF mutation and upregulation of p 16Ink 4a expression appears to be a useful indicator of induction of Senescence.