Institution
Wacker Chemie
Company•Adrian, Michigan, United States•
About: Wacker Chemie is a company organization based out in Adrian, Michigan, United States. It is known for research contribution in the topics: Organosilicon & Alkyl. The organization has 3322 authors who have published 4768 publications receiving 31115 citations. The organization is also known as: Wacker Chemie AG.
Topics: Organosilicon, Alkyl, Catalysis, Silicone, Silicon
Papers published on a yearly basis
Papers
More filters
TL;DR: In this article, the key catalytic reaction for the production of organosilicon compounds, such as organofunctional silanes and silicones, is used for crosslinking of silicone polymers to elastomers and silicone-based release coatings, and for coupling of silane and siloxanes to organic polymers.
458 citations
TL;DR: It is shown that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model.
Abstract: Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need1–3. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative4. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons5. This model demonstrated long-term acceptance of discordant xenografts with safe immunosuppression but did not predict their life-supporting function. Despite 25 years of extensive research, the maximum survival of a baboon after heart replacement with a porcine xenograft was only 57 days and this was achieved, to our knowledge, only once6. Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. Consistent life-supporting function of xenografted hearts for up to 195 days is a milestone on the way to clinical cardiac xenotransplantation7.
315 citations
205 citations
28 Apr 2008
TL;DR: In this paper, Reactive Intermediates Molecular Inorganic Silicon Chemistry Silicon in Transition Metal Chemistry and Silicon in Organic and Bioorganic Chemistry Organosilicon Compounds for Industrial Applications Silicon-Based Materials.
Abstract: From the Contents: Reactive Intermediates Molecular Inorganic Silicon Chemistry Silicon in Transition Metal Chemistry Silicon in Organic and Bioorganic Chemistry Organosilicon Compounds for Industrial Applications Silicon-Based Materials
178 citations
TL;DR: In this paper, the influence of one selected superplasticizer on the hydration of the Portland cement was examined and it was shown that the super plasticizer in question retards both the aluminate reaction and the silicate reaction.
157 citations
Authors
Showing all 3322 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ullrich Scherf | 92 | 735 | 36972 |
| Johannes A. Lercher | 83 | 673 | 28873 |
| Bernard P. Binks | 80 | 354 | 25006 |
| Manfred Schmidt | 63 | 244 | 15131 |
| Michael A. Brook | 49 | 353 | 9806 |
| Thomas L. Koch | 46 | 303 | 9294 |
| Markus J. Ege | 41 | 105 | 7711 |
| Norbert Hampp | 34 | 228 | 5271 |
| Tommy S. Horozov | 28 | 60 | 3924 |
| Yang Chen | 24 | 53 | 1813 |
| Lorenz Sigl | 23 | 82 | 2736 |
| Karsten Siems | 22 | 86 | 1625 |
| Gerhard Roewer | 21 | 135 | 1438 |
| Bernward Dipl Chem Dr Deubzer | 20 | 194 | 1529 |
| Johann Weis | 18 | 46 | 1030 |