J
Jussi Paananen
Researcher at University of Eastern Finland
Publications - 92
Citations - 3539
Jussi Paananen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Type 2 diabetes & Population. The author has an hindex of 30, co-authored 82 publications receiving 2857 citations.
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Journal ArticleDOI
Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
Alena Stančáková,Mete Civelek,Niyas K. Saleem,Pasi Soininen,Antti J. Kangas,Henna Cederberg,Jussi Paananen,Jussi Pihlajamäki,Lori L. Bonnycastle,Mario A. Morken,Michael Boehnke,Päivi Pajukanta,Aldons J. Lusis,Francis S. Collins,Johanna Kuusisto,Mika Ala-Korpela,Markku Laakso +16 more
TL;DR: The levels of branched-chain, aromatic amino acids and alanine increased and the levels of glutamine and histidine decreased with increasing glycemia, reflecting, at least in part, insulin resistance.
Journal ArticleDOI
Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)
M. I. J. Uusitupa,Kjeld Hermansen,Markku J. Savolainen,Ursula Schwab,Marjukka Kolehmainen,Lea Brader,Lene S. Mortensen,Lieselotte Cloetens,Anna Johansson-Persson,Gunilla Önning,Mona Landin-Olsson,K-H Herzig,Janne Hukkanen,Fredrik Rosqvist,David Iggman,Jussi Paananen,Kari Pulkki,Maritta Siloaho,Maritta Siloaho,Lars O. Dragsted,Thaer Barri,Kim Overvad,Kim Overvad,K. E. Bach Knudsen,Mette Skou Hedemann,Peter Arner,Ingrid Dahlman,Grethe Iren A. Borge,P Baardseth,Stine Marie Ulven,Ingibjorg Gunnarsdottir,Sigrun Jónsdóttir,Inga Thorsdottir,Matej Orešič,Kaisa Poutanen,Kaisa Poutanen,Ulf Risérus,Björn Åkesson +37 more
TL;DR: The effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome are investigated.
Journal ArticleDOI
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
Vanessa D. de Mello,Jussi Paananen,Jaana Lindström,Maria Lankinen,Lin Shi,Johanna Kuusisto,Jussi Pihlajamäki,Seppo Auriola,Marko Lehtonen,Olov Rolandsson,Ingvar A. Bergdahl,Elise Nordin,Pirjo Ilanne-Parikka,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Rikard Landberg,Rikard Landberg,Johan G. Eriksson,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kati Hanhineva,Matti Uusitupa +22 more
TL;DR: It is suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function.
Journal ArticleDOI
Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
Alena Stančáková,Teemu Kuulasmaa,Jussi Paananen,Anne U. Jackson,Lori L. Bonnycastle,Francis S. Collins,Michael Boehnke,Johanna Kuusisto,Markku Laakso +8 more
TL;DR: Eight type 2 diabetes–related loci were significantly or nominally associated with impaired early-phase insulin release and effects of SLC30A8, HHEX, CDKAL1, and TCF7L2 on insulin release could be partially explained by impaired proinsulin conversion.
Journal ArticleDOI
Nontargeted Metabolite Profiling Discriminates Diet-Specific Biomarkers for Consumption of Whole Grains, Fatty Fish, and Bilberries in a Randomized Controlled Trial
Kati Hanhineva,Maria Lankinen,Anna Pedret,Ursula Schwab,Marjukka Kolehmainen,Jussi Paananen,Vanessa D. de Mello,Rosa Solà,Marko Lehtonen,Kaisa Poutanen,Kaisa Poutanen,Matti Uusitupa,Hannu Mykkänen +12 more
TL;DR: Novel biomarkers of the intake of health-beneficial food items included in the Nordic diet were identified by the metabolite profiling of fasting plasma and confirmed by the correlation analyses with dietary records.