S
Siri Ram Chhabra
Researcher at University of Nottingham
Publications - 84
Citations - 11332
Siri Ram Chhabra is an academic researcher from University of Nottingham. The author has contributed to research in topics: Quorum sensing & Homoserine. The author has an hindex of 43, co-authored 83 publications receiving 10685 citations. Previous affiliations of Siri Ram Chhabra include Salisbury University & Umeå University.
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Journal ArticleDOI
Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
Kay H. McClean,Michael K. Winson,Leigh Fish,Adrian Taylor,Siri Ram Chhabra,Miguel Cámara,Mavis Daykin,John H. Lamb,Simon Swift,Barrie W. Bycroft,Gordon S. A. B. Stewart,Paul Williams +11 more
TL;DR: The ability of CV026 to respond to a series of synthetic AHL and N-acylhomocysteine thiolactone (AHT) analogues is explored, greatly extending the ability to detect a wide spectrum of AHL signal molecules.
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N-Acylhomoserine Lactones Undergo Lactonolysis in a pH-, Temperature-, and Acyl Chain Length-Dependent Manner during Growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
Edwin A. Yates,Bodo Philipp,Catherine M. F. Buckley,Steve Atkinson,Siri Ram Chhabra,R. Elizabeth Sockett,Morris Goldner,Yves Dessaux,Miguel Cámara,Harry Smith,Paul Williams +10 more
TL;DR: Data show that to be functional under physiological conditions in mammalian tissue fluids, AHLs require an N-acyl side chain of at least four carbons in length and that the longer the acyl side chain the more stable the AHL signal molecule.
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Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing
Michael K. Winson,Simon Swift,Leigh Fish,John P. Throup,Frieda Jørgensen,Siri Ram Chhabra,Barrie W. Bycroft,Paul Williams,Gordon S. A. B. Stewart +8 more
TL;DR: Plasmid reporter vectors have been constructed which respond to activation of LuxR and its homologues LasR and RhlR by N-acyl homoserine lactones by AHLs, allowing a comprehensive evaluation of quorum sensing signals from a test organism.
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The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasR
Stephen P. Diggle,Klaus Winzer,Siri Ram Chhabra,Kathryn E. Worrall,Miguel Cámara,Paul Williams +5 more
TL;DR: It is shown that 2‐heptyl‐3‐hydroxy‐4(1H)‐quinolone (PQS) is also an integral component of the quorum sensing circuitry and is required for the production of rhl‐dependent exoproducts at the onset of stationary phase of Pseudomonas aeruginosa.
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Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.
Matthew T. G. Holden,Siri Ram Chhabra,Rocky de Nys,Paul Stead,Nigel J. Bainton,Philip J. Hill,Mike Manefield,Naresh Kumar,Maurice Labatte,Dacre England,Scott A. Rice,Michael Givskov,George P. C. Salmond,Gordon S. A. B. Stewart,Barrie W. Bycroft,Staffan Kjelleberg,Paul Williams +16 more
TL;DR: In this article, the diketopiperazines (DKPs) were found to activate the N-acylhomoserine lactone (AHL) biosensor in a concentration-dependent manner.