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Siriruk Changrob
Researcher at University of Chicago
Publications - Â 30
Citations - Â 496
Siriruk Changrob is an academic researcher from University of Chicago. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 10, co-authored 23 publications receiving 222 citations. Previous affiliations of Siriruk Changrob include Mahidol University.
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Journal ArticleDOI
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike.
Jenna J. Guthmiller,Olivia Stovicek,Jiaolong Wang,Siriruk Changrob,Lei Li,Peter Halfmann,Nai Ying Zheng,Henry A. Utset,Christopher T. Stamper,Haley L. Dugan,William D. Miller,Min Huang,Ya-Nan Dai,Christopher A. Nelson,Paige D. Hall,Maud O. Jansen,Kumaran Shanmugarajah,Jessica S. Donington,Florian Krammer,Daved H. Fremont,Andrzej Joachimiak,Andrzej Joachimiak,Yoshihiro Kawaoka,Vera Tesic,Maria Lucia Madariaga,Patrick C. Wilson +25 more
TL;DR: In this article, the authors reported that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and nonstructural proteins.
Journal ArticleDOI
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets.
Haley L. Dugan,Christopher T. Stamper,Lei Li,Siriruk Changrob,Nicholas Asby,Peter Halfmann,Nai Ying Zheng,Min Huang,Dustin G. Shaw,Mari Cobb,Steven A. Erickson,Jenna J. Guthmiller,Olivia Stovicek,Jiaolong Wang,Emma S. Winkler,Maria Lucia Madariaga,Kumaran Shanmugarajah,Maud O. Jansen,Fatima Amanat,Isabelle Stewart,Henry A. Utset,Jun Huang,Christopher A. Nelson,Ya Nan Dai,Paige D. Hall,Robert Jedrzejczak,Robert Jedrzejczak,Andrzej Joachimiak,Andrzej Joachimiak,Florian Krammer,Michael S. Diamond,Daved H. Fremont,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Patrick C. Wilson +34 more
TL;DR: The authors used single-cell sequencing to profile SARS-CoV-2-reactive B cells in 38 COVID-19 patients, using oligo-tagged antigen baits.
Journal ArticleDOI
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
Haley L. Dugan,Jenna J. Guthmiller,Philip Arevalo,Min Huang,Yao-Qing Chen,Karlynn E. Neu,Carole Henry,Nai-Ying Zheng,Linda Yu-Ling Lan,Micah E. Tepora,Olivia Stovicek,Dalia J. Bitar,Anna-Karin E. Palm,Christopher T. Stamper,Siriruk Changrob,Henry A. Utset,Lynda Coughlan,Florian Krammer,Sarah Cobey,Patrick C. Wilson +19 more
TL;DR: The findings demonstrate that existing influenza-specific memory and route of exposure influence influenza immunity, and reveal that both preexisting immunity and exposure type shape protective antibody responses to conserved influenza virus epitopes in humans.
Posted ContentDOI
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike
Jenna J. Guthmiller,Olivia Stovicek,Jiaolong Wang,Siriruk Changrob,Lei Li,Peter Halfmann,Nai Ying Zheng,Henry A. Utset,Christopher T. Stamper,Haley L. Dugan,William D. Miller,Min Huang,Ya-Nan Dai,Christopher A. Nelson,Paige D. Hall,Maud O. Jansen,Kumaran Shanmugarajah,Jessica S. Donington,Florian Krammer,Daved H. Fremont,Andrzej Joachimiak,Andrzej Joachimiak,Yoshihiro Kawaoka,Vera Tesic,Maria Lucia Madariaga,Patrick C. Wilson +25 more
TL;DR: It is reported that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and non-structural proteins.
Journal ArticleDOI
Imprinting, immunodominance, and other impediments to generating broad influenza immunity.
TL;DR: What immune imprinting means to immunologists is discussed and efforts to overcome or silence imprinting in order to improve vaccination efficiency are described.