S
Siu-Cheung Tam
Researcher at The Chinese University of Hong Kong
Publications - 54
Citations - 2202
Siu-Cheung Tam is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Trichosanthin & Ribosome-inactivating protein. The author has an hindex of 25, co-authored 54 publications receiving 2082 citations. Previous affiliations of Siu-Cheung Tam include University of Toronto & Academia Sinica.
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Journal ArticleDOI
Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
Cynthia M. Beall,Gianpiero L. Cavalleri,Libin Deng,Robert C. Elston,Gao Yang,Jo Knight,Chaohua Li,Jiang Chuan Li,Yu Liang,Mark McCormack,Hugh Montgomery,Hao Pan,Peter A. Robbins,Kevin V. Shianna,Siu-Cheung Tam,Ngodrop Tsering,Krishna R. Veeramah,Wei Wang,Puchung Wangdui,Michael E. Weale,Yaomin Xu,Zhe Xu,Ling Yang,M Justin Zaman,Changqing Zeng,Li Zhang,Xianglong Zhang,Pingcuo Zhaxi,Yong-Tang Zheng +28 more
TL;DR: Evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants.
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Soluble dextran-hemoglobin complex as a potential blood substitute.
TL;DR: A complex between soluble dextran and human hemoglobin has been synthesized by two different methods and in the rabbit, the complex obtained by the alkylation method was excreted by the kidneys and cleared from the circulation much more slowly than free hemoglobin.
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Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation.
TL;DR: The present results suggest that PEG20k is better than PEG5k for reducing immunogenicity and prolonging plasma half-life of trichosanthin and the conjugate can become a better therapeutic agent.
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Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro.
Jian-Hua Wang,Siu-Cheung Tam,Hai Huang,Dong-Yun Ouyang,Dong-Yun Ouyang,Yuan-Yuan Wang,Yuan-Yuan Wang,Yong-Tang Zheng +7 more
TL;DR: The in vitro study showed that the anti-HIV activity of PEGylated TCS was retained with reduced potency, and the in vivo activity is expected to have only slightly changed due to other beneficial effects like prolonged half-life.
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The anti-HIV-1 effect of scutellarin
TL;DR: Scutellarin was found to inhibit several strains of HIV-1 replication with different potencies, and appeared to inhibit HIV- 1 RT activity, HIV-2 particle attachment and cell fusion, which are essential activities for viral transmission and replication.