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Ben Youngblood
Researcher at St. Jude Children's Research Hospital
Publications - 48
Citations - 3611
Ben Youngblood is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 22, co-authored 40 publications receiving 2461 citations. Previous affiliations of Ben Youngblood include Emory University & University of California, Santa Barbara.
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Journal ArticleDOI
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
Hazem E. Ghoneim,Yiping Fan,Ardiana Moustaki,Hossam A. Abdelsamed,Pradyot Dash,Pranay Dogra,Robert Carter,Walid Awad,Geoff Neale,Paul G. Thomas,Ben Youngblood +10 more
TL;DR: It is reported that blocking de novo DNA methylation in activated CD8 T cells allows them to retain their effector functions despite chronic stimulation during a persistent viral infection.
Journal ArticleDOI
Origin and differentiation of human memory CD8 T cells after vaccination
Rama Akondy,Mark Fitch,Srilatha Edupuganti,Shu Yang,Haydn T. Kissick,Kelvin Li,Ben Youngblood,Ben Youngblood,Hossam A. Abdelsamed,Donald J. McGuire,Kristen W. Cohen,Gabriela Alexe,Gabriela Alexe,Shashi Nagar,Megan McCausland,Satish Gupta,Pramila Tata,W. Nicholas Haining,W. Nicholas Haining,M. Juliana McElrath,David W. Zhang,Bin Hu,William J. Greenleaf,Jörg J. Goronzy,Mark J. Mulligan,Marc K. Hellerstein,Rafi Ahmed +26 more
TL;DR: Open chromatin profile at effector genes was maintained in memory CD8 T cells isolated even a decade after vaccination, indicating that these cells retain an epigenetic fingerprint of their effector history and remain poised to respond rapidly upon re-exposure to the pathogen.
Journal ArticleDOI
Effector CD8 T cells dedifferentiate into long-lived memory cells
Ben Youngblood,Ben Youngblood,J. Scott Hale,Haydn T. Kissick,Eunseon Ahn,Xiaojin Xu,Andreas Wieland,Koichi Araki,Erin E. West,Hazem E. Ghoneim,Yiping Fan,Pranay Dogra,Carl W. Davis,Bogumila T. Konieczny,Rustom Antia,Xiaodong Cheng,Rafi Ahmed +16 more
TL;DR: Epic repression of naive-associated genes in effector CD8 T cells can be reversed in cells that develop into long-lived memory T cells while key effector genes remain demethylated, demonstrating thatMemory T cells arise from a subset of fate-permissive effector T cells.
Journal ArticleDOI
Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection
J. Scott Hale,Ben Youngblood,Donald R. Latner,Ata Ur Rasheed Mohammed,Lilin Ye,Rama Akondy,Tuoqi Wu,Smita S. Iyer,Rafi Ahmed +8 more
TL;DR: These findings indicate that CD4(+) memory T cells "remember" their previous effector lineage after antigen clearance, being poised to reacquire their lineage-specific effector functions upon antigen reencounter.
Journal ArticleDOI
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
Hu Zeng,Sivan Cohen,Cliff Guy,Sharad Shrestha,Geoffrey Neale,Scott A. Brown,Caryn Cloer,Rigel J. Kishton,Xia Gao,Ben Youngblood,Mytrang H. Do,Ming O. Li,Jason W. Locasale,Jeffrey C. Rathmell,Jeffrey C. Rathmell,Hongbo Chi +15 more
TL;DR: It is reported here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essential for Tfh cell differentiation and GC reaction under steady state and after antigen immunization and viral infection.