mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
Hu Zeng,Sivan Cohen,Cliff Guy,Sharad Shrestha,Geoffrey Neale,Scott A. Brown,Caryn Cloer,Rigel J. Kishton,Xia Gao,Ben Youngblood,Mytrang H. Do,Ming O. Li,Jason W. Locasale,Jeffrey C. Rathmell,Jeffrey C. Rathmell,Hongbo Chi +15 more
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TLDR
It is reported here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essential for Tfh cell differentiation and GC reaction under steady state and after antigen immunization and viral infection.About:
This article is published in Immunity.The article was published on 2016-09-20 and is currently open access. It has received 254 citations till now. The article focuses on the topics: Germinal center & mTORC2.read more
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Metabolic Instruction of Immunity
TL;DR: This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
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Unraveling the Complex Interplay Between T Cell Metabolism and Function
TL;DR: How T cell metabolism can have profound effects on health and disease and where it might be a promising target to treat a variety of pathologies is discussed.
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Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Xiaoyun Li,Mathias Wenes,Pedro Romero,Stanley Ching-Cheng Huang,Sarah-Maria Fendt,Sarah-Maria Fendt,Ping-Chih Ho +6 more
TL;DR: An overview of the pathways of cancer metabolism that intersect with immunometabolism, typically resulting in immunosuppression, is provided, with a focus on how these metabolic pathways could be targeted in order to enhance anticancer immunity and immunotherapy.
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Metabolic coordination of T cell quiescence and activation.
TL;DR: It is proposed that immunological cues and nutrients license and tune metabolic programmes and signalling networks that communicate in a bidirectional manner to promote quiescence exit and how cell-extrinsic factors, such as nutrients and regulatory T cells, directly and indirectly balance quiescent and activation programmes in conventional T cells.
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The spectrum of T cell metabolism in health and disease
TL;DR: The idea that the spectrum of immune cell metabolic states can provide a basis for categorizing human diseases is introduced and the metabolic and interlinked signalling requirements of T cells responding to acute infection are summarized.
References
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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Ruoning Wang,Christopher P. Dillon,Lewis Zhichang Shi,Sandra Milasta,Robert Carter,David Finkelstein,Laura L. McCormick,Patrick Fitzgerald,Hongbo Chi,Joshua Munger,Douglas R. Green +10 more
TL;DR: Metabolic tracer analysis revealed a Myc-dependent metabolic pathway linking glutaminolysis to the biosynthesis of polyamines, which may represent a general mechanism for metabolic reprogramming under patho-physiological conditions.
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T follicular helper cell differentiation, function, and roles in disease
TL;DR: There has been dramatic advances in this young field, but there is much to be learned about Tfh cell biology in the interest of applying that knowledge to biomedical needs.
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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Zhichang Shi,Ruoning Wang,Gonghua Huang,Peter Vogel,Geoffrey Neale,Douglas R. Green,Hongbo Chi +6 more
TL;DR: HIF1α induction by mTOR represents a metabolic checkpoint for the differentiation of TH17 and Treg cells and is associated with good progenitor cell status in mice.
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Foxp3+ follicular regulatory T cells control the germinal center response
Michelle A. Linterman,Wim Pierson,Sau K. Lee,Axel Kallies,Shimpei Kawamoto,Tim F. Rayner,Monika Srivastava,Devina Divekar,Laura L. Beaton,Jennifer J. Hogan,Sidonia Fagarasan,Adrian Liston,Kenneth G. C. Smith,Carola G. Vinuesa +13 more
TL;DR: A population of Foxp3+Blimp-1+CD4+ T cells constituting 10–25% of the CXCR5highPD-1highCD4- T cells found in the germinal center after immunization with protein antigens are described.
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Metabolic regulation of T lymphocytes.
TL;DR: The role of cellular metabolism in T cell development, activation, differentiation, and function is discussed to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.