Sogyong L. Auh

TL;DR: It is reported that reduction of tumor burden after ablative RT depends largely on T-cell responses, and the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity is emphasized.

TL;DR: It is revealed that local high-dose RT can trigger production of type I IFN that initiates a cascading innate and adaptive immune attack on the tumor, and the antitumor effect of RT is abolished in type IIFN nonresponsive hosts.

TL;DR: It is shown here that an unleashed innate immune response due to the absence of residential T cells can also be a direct cause of death.

TL;DR: It is shown that T cells are sufficient and necessary to control the early inflammatory response to LPS and that an uncontrolled proinflammatory innate response due to inadequate T cells makes neonates more vulnerable to TLR agonists or viral infection.

TL;DR: Targeting the primary tumor with Ad-LIGHT before surgical excision is a new strategy to elicit better immune response for the eradication of spontaneous metastases and clearly shows with a fibrosarcoma model Ag104Ld that local treatment can generate plenty of tumor-specific CTL that exit thePrimary tumor and infiltrate distal tumors to completely eradicatedistal tumors.