W
Weilai Dong
Researcher at Yale University
Publications - 42
Citations - 1429
Weilai Dong is an academic researcher from Yale University. The author has contributed to research in topics: Exome sequencing & Medicine. The author has an hindex of 12, co-authored 30 publications receiving 739 citations. Previous affiliations of Weilai Dong include Zhejiang University & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Scott N. Gettinger,Jungmin Choi,Katherine Hastings,Anna Truini,Ila Datar,Ryan T. Sowell,Anna Wurtz,Weilai Dong,Guoping Cai,Mary Ann Melnick,Victor Y. Du,Joseph Schlessinger,Sarah B. Goldberg,Anne C. Chiang,Miguel F. Sanmamed,Ignacio Melero,Jackeline Agorreta,Luis M. Montuenga,Richard P. Lifton,Soldano Ferrone,Paula B. Kavathas,David L. Rimm,Susan M. Kaech,Kurt A. Schalper,Roy S. Herbst,Katerina Politi +25 more
TL;DR: CRISPR-mediated knockout of B2m in an immunocompetent lung cancer mouse model conferred resistance to PD-1 blockade in vivo, proving its role in resistance to ICIs.
Journal ArticleDOI
Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
Ila Datar,Ila Datar,Miguel F. Sanmamed,Miguel F. Sanmamed,Jun Wang,Brian S. Henick,Brian S. Henick,Jungmin Choi,Ti Badri,Weilai Dong,Nikita Mani,Maria I. Toki,Luis Mejías,Maria D. Lozano,Jose Luis Perez-Gracia,Vamsidhar Velcheti,Matthew D. Hellmann,Matthew D. Hellmann,Justin F. Gainor,Kristen McEachern,David Jenkins,Konstantinos N. Syrigos,Katerina Politi,Katerina Politi,Scott N. Gettinger,David L. Rimm,David L. Rimm,Roy S. Herbst,Ignacio Melero,Lieping Chen,Kurt A. Schalper,Kurt A. Schalper +31 more
TL;DR: In baseline samples from 90 patients with advanced NSCLC treated with PD-1 axis blockers, elevated LAG-3 was significantly associated with shorter progression-free survival, suggesting independence of these immune evasion pathways.
Journal ArticleDOI
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
Scott N. Gettinger,June-Seek Choi,Nikita Mani,Nikita Mani,Miguel F. Sanmamed,Ila Datar,Ila Datar,Ryan T. Sowell,Victor Y. Du,Edward Kaftan,Sarah B. Goldberg,Weilai Dong,Daniel Zelterman,Katerina Politi,Katerina Politi,Paula B. Kavathas,Susan M. Kaech,Xiaoqing Yu,Hongyu Zhao,Joseph Schlessinger,Richard P. Lifton,David L. Rimm,David L. Rimm,Lieping Chen,Roy S. Herbst,Kurt A. Schalper,Kurt A. Schalper +26 more
TL;DR: It is demonstrated that dormant TILs can be reinvigorated upon PD-1 blockade in a patient-derived xenograft model and a “dormant” T-cell signature associated with sensitivity to ICB is identified.
Journal ArticleDOI
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Sheng Chih Jin,Sheng Chih Jin,Sheng Chih Jin,Weilai Dong,Weilai Dong,Adam J. Kundishora,Shreyas Panchagnula,Andres Moreno-De-Luca,Charuta G. Furey,Charuta G. Furey,August A Allocco,Rebecca L. Walker,Carol Nelson-Williams,Hannah Smith,Ashley Dunbar,Sierra B Conine,Qiongshi Lu,Xue Zeng,Xue Zeng,Michael C. Sierant,Michael C. Sierant,James R. Knight,William J. Sullivan,Phan Q. Duy,Tyrone DeSpenza,Benjamin C. Reeves,Jason K. Karimy,Arnaud Marlier,Christopher Castaldi,Irina Tikhonova,Boyang Li,Helena Perez Pena,James R. Broach,Edith Mbabazi Kabachelor,Peter Ssenyonga,Christine Hehnly,Li Ge,Boris Keren,Andrew T. Timberlake,June Goto,Francesco T. Mangano,James M. Johnston,William E. Butler,Benjamin C. Warf,Edward R. Smith,Steven J. Schiff,David D. Limbrick,Gregory G. Heuer,Eric M. Jackson,Bermans J. Iskandar,Shrikant Mane,Shozeb Haider,Bulent Guclu,Yasar Bayri,Yener Sahin,Charles C. Duncan,Michael L.J. Apuzzo,Michael L. DiLuna,Ellen J. Hoffman,Nenad Sestan,Laura R. Ment,Seth L. Alper,Kaya Bilguvar,Daniel H. Geschwind,Murat Gunel,Richard P. Lifton,Richard P. Lifton,Kristopher T. Kahle +67 more
TL;DR: Through whole-exome sequencing of 381 patients with sporadic, neurosurgically treated CH, it is found that damaging de novo mutations account for >17% of cases, with five different genes exhibiting a significant de noVO mutation burden.
Journal ArticleDOI
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology
Norman G. Nicolson,Timothy D. Murtha,Weilai Dong,Johan O. Paulsson,Jungmin Choi,Andrea Barbieri,Taylor C. Brown,John W. Kunstman,Catharina Larsson,Manju L. Prasad,Reju Korah,Richard P. Lifton,C. Christofer Juhlin,Tobias Carling +13 more
TL;DR: Though the number and variety of somatic variants are similar in the different histopathological subtypes of FTC in this study, mutational burden was an independent predictor of mortality and recurrence.