R
Ryan T. Sowell
Researcher at Yale University
Publications - 16
Citations - 1665
Ryan T. Sowell is an academic researcher from Yale University. The author has contributed to research in topics: Cancer & Cytotoxic T cell. The author has an hindex of 11, co-authored 15 publications receiving 1215 citations. Previous affiliations of Ryan T. Sowell include Rush University Medical Center.
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Journal ArticleDOI
Metabolic Instruction of Immunity
TL;DR: This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
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Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Scott N. Gettinger,Jungmin Choi,Katherine Hastings,Anna Truini,Ila Datar,Ryan T. Sowell,Anna Wurtz,Weilai Dong,Guoping Cai,Mary Ann Melnick,Victor Y. Du,Joseph Schlessinger,Sarah B. Goldberg,Anne C. Chiang,Miguel F. Sanmamed,Ignacio Melero,Jackeline Agorreta,Luis M. Montuenga,Richard P. Lifton,Soldano Ferrone,Paula B. Kavathas,David L. Rimm,Susan M. Kaech,Kurt A. Schalper,Roy S. Herbst,Katerina Politi +25 more
TL;DR: CRISPR-mediated knockout of B2m in an immunocompetent lung cancer mouse model conferred resistance to PD-1 blockade in vivo, proving its role in resistance to ICIs.
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A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
Scott N. Gettinger,June-Seek Choi,Nikita Mani,Nikita Mani,Miguel F. Sanmamed,Ila Datar,Ila Datar,Ryan T. Sowell,Victor Y. Du,Edward Kaftan,Sarah B. Goldberg,Weilai Dong,Daniel Zelterman,Katerina Politi,Katerina Politi,Paula B. Kavathas,Susan M. Kaech,Xiaoqing Yu,Hongyu Zhao,Joseph Schlessinger,Richard P. Lifton,David L. Rimm,David L. Rimm,Lieping Chen,Roy S. Herbst,Kurt A. Schalper,Kurt A. Schalper +26 more
TL;DR: It is demonstrated that dormant TILs can be reinvigorated upon PD-1 blockade in a patient-derived xenograft model and a “dormant” T-cell signature associated with sensitivity to ICB is identified.
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Cutting Edge: Generation of Effector Cells That Localize to Mucosal Tissues and Form Resident Memory CD8 T Cells Is Controlled by mTOR
TL;DR: The ability of rapamycin to block the formation of functional resident CD8 T cells in mucosal tissues protected mice from a model ofCD8 T cell–mediated lethal intestinal autoimmunity.
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Effects of cryopreservation on effector cells for antibody dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cell activity in (51)Cr-release and CD107a assays.
TL;DR: The objective was to determine the effects of cryopreservation of effector PBMC on cell frequency, and on the magnitude and specificity of ADCC and NK activity.