A
Anna Truini
Researcher at Yale University
Publications - 36
Citations - 1719
Anna Truini is an academic researcher from Yale University. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 19, co-authored 36 publications receiving 1319 citations. Previous affiliations of Anna Truini include National Cancer Research Institute & University of Genoa.
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Journal ArticleDOI
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Scott N. Gettinger,Jungmin Choi,Katherine Hastings,Anna Truini,Ila Datar,Ryan T. Sowell,Anna Wurtz,Weilai Dong,Guoping Cai,Mary Ann Melnick,Victor Y. Du,Joseph Schlessinger,Sarah B. Goldberg,Anne C. Chiang,Miguel F. Sanmamed,Ignacio Melero,Jackeline Agorreta,Luis M. Montuenga,Richard P. Lifton,Soldano Ferrone,Paula B. Kavathas,David L. Rimm,Susan M. Kaech,Kurt A. Schalper,Roy S. Herbst,Katerina Politi +25 more
TL;DR: CRISPR-mediated knockout of B2m in an immunocompetent lung cancer mouse model conferred resistance to PD-1 blockade in vivo, proving its role in resistance to ICIs.
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Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer
Jacqulyne P. Robichaux,Yasir Elamin,Zhi Tan,Brett W. Carter,Shuxing Zhang,Shengwu Liu,Shuai Li,Ting Chen,Alissa Poteete,Adriana Estrada-Bernal,Anh T. Le,Anna Truini,Monique B. Nilsson,Huiying Sun,Emily Roarty,Sarah B. Goldberg,Julie R. Brahmer,Mehmet Altan,Charles Lu,Vassiliki A. Papadimitrakopoulou,Katerina Politi,Robert C. Doebele,Kwok-Kin Wong,John V. Heymach +23 more
TL;DR: These data identify poziotinib as a potent, clinically active inhibitor of EGFR and HER2 exon 20 mutations and illuminate the molecular features of TKIs that may circumvent steric changes induced by these mutations.
Journal ArticleDOI
Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes
Saravana M. Dhanasekaran,O. Alejandro Balbin,Guoan Chen,Ernest Nadal,Shanker Kalyana-Sundaram,Jincheng Pan,Brendan A. Veeneman,Xuhong Cao,Rohit Malik,Pankaj Vats,Rui Wang,Stephanie Huang,Jinjie Zhong,Xiaojun Jing,Matthew K. Iyer,Yi-Mi Wu,Paul W. Harms,Jules Lin,Rishindra M. Reddy,Christine Brennan,Nallasivam Palanisamy,Andrew C. Chang,Anna Truini,Mauro Truini,Dan R. Robinson,David G. Beer,Arul M. Chinnaiyan +26 more
TL;DR: It is shown that higher numbers of gene fusions is an independent prognostic factor for poor survival in lung cancer and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumors without known driver mutations.
Journal ArticleDOI
A Novel Serum 4-microRNA Signature for Lung Cancer Detection.
Ernest Nadal,Anna Truini,Asuka Nakata,Jules Lin,Rishindra M. Reddy,Andrew C. Chang,Nithya Ramnath,Noriko Gotoh,David G. Beer,Guoan Chen +9 more
TL;DR: A serum 4-miRNA signature was identified that discriminated with high accuracy lung cancer patients from NC and further prospective validation of this miRNA signature is warranted.
Journal ArticleDOI
Clinical Applications of Circulating Tumor Cells in Lung Cancer Patients by CellSearch System
Anna Truini,Angela Alama,Maria Giovanna Dal Bello,Simona Coco,Irene Vanni,Erika Rijavec,Carlo Genova,Giulia Barletta,Federica Biello,Francesco Grossi +9 more
TL;DR: The significance of CTC detection in lung cancer is examined through the analysis of the published studies in both non-small cell and small cell lung cancers; additionally, the prognostic and the clinical role of C TC enumeration in treatment monitoring will be reported and discussed.