S
Soma Das
Researcher at University of Chicago
Publications - 162
Citations - 29990
Soma Das is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 55, co-authored 160 publications receiving 22523 citations. Previous affiliations of Soma Das include University of Illinois at Chicago & NorthShore University HealthSystem.
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Journal ArticleDOI
Role of HNF-1α in the regulation of UGT1A1, UGT1A9 and UGT2B7 MRNA expression
Snezana Mirkov,Federico Innocenti,Wanqing Liu,Peixian Chen,Jacqueline Ramírez,Samir D. Undevia,Soma Das,Mark J. Ratain +7 more
TL;DR: This work aims to investigate the role of HNF‐1α in the regulation of the expression of UGT1A1, U GT1A9 and UGT2B7 in nondiabetic individuals and its effect on HNF1‐α function is unknown.
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Genetic Polymorphisms and the Toxicity of Antileukemic Agents in Children with Acute Lymphoblastic Leukemia.
Shinji Kishi,Cheng Cheng,Deqing Pei,Soma Das,Edwin H. Cook,Nobuko Hijiya,Carmelo Rizzari,Gary L. Rosner,Ching-Hon Pui,William E. Evans,Mary V. Relling +10 more
TL;DR: It is concluded that germline polymorphisms influence the toxicity of antileukemic therapy and their identification may provide a tool for tailoring therapy in childhood ALL.
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Haplotype analysis of UGT1A1 and UGT1A9 gene polymorphisms related to the glucuronidation of SN-38, the active metabolite of irinotecan
Wanqing Liu,Federico Innocenti,Peixian Chen,Ankit A. Desai,Carrie Grimsley,A. Di Rienzo,Soma Das,M. J. Ratain +7 more
TL;DR: The haplotypes of UGT1A1-UGT1A9 haplotypes might have a different phenotypic effect compared to single variants, and a T indel in the 5' untranslated region has been associated with altered gene expression.
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Erratum: Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancer (Hum Genet (2000) 107 (186-191))
Qing Gao,Gail Tomlinson,Soma Das,Shelly Cummings,Lise Sveen,James D. Fackenthal,Phil Schumm,Olufunmilayo I. Olopade +7 more
TL;DR: It is concluded that African Americans have a unique mutation spectrum in BRCA1 and BRCa2 genes, but recurrent mutations are likely to be more widely dispersed and therefore not readily identifiable in this population.
Journal Article
Molecular evidence that the p55 gene is not responsible for either of two Xq28-linked disorders: Emery-Dreifuss muscular dystrophy and dyskeratosis congenita.
TL;DR: It is highly unlikely that mutations in the p55 gene are responsible for any cases of dyskeratosis congenita or Emergy-Dreifuss muscular dystrophy, and one candidate is the Xq28-linked gene MPP-1, which encodes the p 55 protein.