S
Somayyeh Fahiminiya
Researcher at McGill University Health Centre
Publications - 16
Citations - 643
Somayyeh Fahiminiya is an academic researcher from McGill University Health Centre. The author has contributed to research in topics: Thyroid cancer & Thyroid carcinoma. The author has an hindex of 10, co-authored 16 publications receiving 413 citations. Previous affiliations of Somayyeh Fahiminiya include McGill University.
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Journal ArticleDOI
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.
Alexandre Janer,Alexandre Janer,Julien Prudent,Julien Prudent,Vincent Paupe,Vincent Paupe,Somayyeh Fahiminiya,Jacek Majewski,Nicolas Sgarioto,Christine Des Rosiers,Christine Des Rosiers,Anick Forest,Anick Forest,Zhen-Yuan Lin,Anne-Claude Gingras,Anne-Claude Gingras,Grant A. Mitchell,Heidi M. McBride,Heidi M. McBride,Eric A. Shoubridge,Eric A. Shoubridge +20 more
TL;DR: In this paper, a homozygous missense mutation in SLC25A46, the mammalian orthologue of Ugo1, in a subject with Leigh syndrome was uncovered, leading to mitochondrial hyperfusion, alterations in endoplasmic reticulum (ER) morphology, impaired cellular respiration, and premature cellular senescence.
Journal Article
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome
Alexandre Janer,Alexandre Janer,Julien Prudent,Julien Prudent,Vincent Paupe,Vincent Paupe,Somayyeh Fahiminiya,Jacek Majewski,Nicolas Sgarioto,Christine Des Rosiers,Christine Des Rosiers,Anick Forest,Anick Forest,Zhen-Yuan Lin,Anne-Claude Gingras,Anne-Claude Gingras,Grant A. Mitchell,Heidi M. McBride,Heidi M. McBride,Eric A. Shoubridge,Eric A. Shoubridge +20 more
TL;DR: Results show that SLC25A46 plays a role in a mitochondrial/ER pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early‐onset neurodegenerative disease and cell fate decisions.
Journal ArticleDOI
Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations
Rebecca D. Chernock,Barbara Rivera,Nicla Borrelli,D. Ashley Hill,Somayyeh Fahiminiya,Tasha Shah,Anne Sophie Chong,Barina Aqil,Mitra Mehrad,Thomas J. Giordano,Rachel Sheridan,Meilan M. Rutter,Meilan M. Rutter,Louis P. Dehner,William D. Foulkes,Yuri E. Nikiforov +15 more
TL;DR: The results of the study demonstrate that childhood- and adolescent-onset PDTC are genetically distinct from adult-onsets PDTC in that they are strongly associated with DICER1 mutations and may herald DICer1 syndrome in a minority.
Journal ArticleDOI
DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma
Jonathan D. Wasserman,Nelly Sabbaghian,Somayyeh Fahiminiya,Rose Chami,Ozgur Mete,Meryl Acker,Mona K Wu,Mona K Wu,Adam Shlien,Leanne de Kock,Leanne de Kock,William D. Foulkes,William D. Foulkes,William D. Foulkes +13 more
TL;DR: DICer1 is a driver of pediatric thyroid nodules, and DICER1-mutated PTC may represent a distinct class of low-risk malignancies.