Z
Zhen-Yuan Lin
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 8
Citations - 1181
Zhen-Yuan Lin is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: mitochondrial fusion & MFN2. The author has an hindex of 7, co-authored 8 publications receiving 1047 citations. Previous affiliations of Zhen-Yuan Lin include Mount Sinai Hospital, Toronto.
Papers
More filters
Journal ArticleDOI
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
Jean-Philippe Lambert,Gordana Ivosev,Amber L. Couzens,Brett Larsen,Mikko Taipale,Zhen-Yuan Lin,Quan Zhong,Susan Lindquist,Susan Lindquist,Marc Vidal,Ruedi Aebersold,Ruedi Aebersold,Tony Pawson,Tony Pawson,Ron Bonner,Stephen A. Tate,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: It is shown that AP-SWATH is a robust label-free approach to characterize changes in protein-protein interactions imparted by the HSP90 inhibitor NVP-AUY922 or melanoma-associated mutations in the human kinase CDK4 and proposed a scalable pipeline for systems biology studies.
A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways
Mikko Taipale,Irina Krykbaeva,Zhen-Yuan Lin,Brett Larsen,Hyungwon Choi,Anne-Claude Gingras,George Tucker,Jian Peng,Bonnie Berger,Susan Lindquist +9 more
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition
Jean-Philippe Lambert,Gordana Ivosev,Amber L. Couzens,Brett Larsen,Mikko Taipale,Zhen-Yuan Lin,Quan Zhong,Susan Lindquist,Susan Lindquist,Marc Vidal,Ruedi Aebersold,Ruedi Aebersold,Tony Pawson,Tony Pawson,Ron Bonner,Stephen A. Tate,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: In this article, changes to protein interactomes as a result of mutations to the bait protein or addition of a pharmacological inhibitor are robustly monitored with affinity purification coupled with data-independent acquisition-based mass spectrometry and an automated data analysis pipeline.
Journal ArticleDOI
Global Gene Deletion Analysis Exploring Yeast Filamentous Growth
Owen Ryan,Rebecca S. Shapiro,Christoph F. Kurat,David Mayhew,Anastasia Baryshnikova,Brian L. Chin,Zhen-Yuan Lin,Michael J. Cox,Frederick S. Vizeacoumar,Doris Cheung,Sondra Bahr,Kyle Tsui,Faiza Tebbji,Faiza Tebbji,Adnane Sellam,Adnane Sellam,Fabian Istel,Tobias Schwarzmüller,Todd B. Reynolds,Karl Kuchler,David K. Gifford,David K. Gifford,Malcolm Whiteway,Malcolm Whiteway,Guri Giaever,Corey Nislow,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Robi D. Mitra,Brenda J. Andrews,Gerald R. Fink,Gerald R. Fink,Leah E. Cowen,Charles Boone +34 more
TL;DR: This work constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain and identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth.
Journal ArticleDOI
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.
Alexandre Janer,Alexandre Janer,Julien Prudent,Julien Prudent,Vincent Paupe,Vincent Paupe,Somayyeh Fahiminiya,Jacek Majewski,Nicolas Sgarioto,Christine Des Rosiers,Christine Des Rosiers,Anick Forest,Anick Forest,Zhen-Yuan Lin,Anne-Claude Gingras,Anne-Claude Gingras,Grant A. Mitchell,Heidi M. McBride,Heidi M. McBride,Eric A. Shoubridge,Eric A. Shoubridge +20 more
TL;DR: In this paper, a homozygous missense mutation in SLC25A46, the mammalian orthologue of Ugo1, in a subject with Leigh syndrome was uncovered, leading to mitochondrial hyperfusion, alterations in endoplasmic reticulum (ER) morphology, impaired cellular respiration, and premature cellular senescence.