Songtao Yu

TL;DR: It is shown that interferon regulatory factor 4 (IRF4) is a critical determinant of the transcriptional response to nutrient availability in adipocytes and the disposition of calories in adipose tissue, with consequences for systemic metabolic homeostasis.

TL;DR: Interferon regulatory factor 4 is identified as a dominant transcriptional effector of thermogenesis and induced by cold and cAMP in adipocytes and is sufficient to promote increased thermogenic gene expression, energy expenditure, and cold tolerance.

TL;DR: Cre recombinase activity in multiple cell populations of the major adipose tissue depots of these and other Cre lines is characterized using the membrane-Tomato/membrane-GFP (mT/mG) dual fluorescent reporter to show that the PdgfRα-Cre line is preferable for studies targeting adipocyte precursor cells in vivo.

TL;DR: The data demonstrate that COUP-TFII represents an endogenous suppressor of adipogenesis, linking antiadipogenic extracellular signals to the core transcriptional cascade.