S
Srinivasulu Chigurupati
Researcher at Food and Drug Administration
Publications - 44
Citations - 3529
Srinivasulu Chigurupati is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Angiogenesis & Neuroprotection. The author has an hindex of 25, co-authored 43 publications receiving 3130 citations. Previous affiliations of Srinivasulu Chigurupati include College of Health Sciences, Bahrain & Johns Hopkins University.
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Journal ArticleDOI
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Sung-Chun Tang,Thiruma V. Arumugam,Thiruma V. Arumugam,Xiangru Xu,Aiwu Cheng,Mohamed R. Mughal,Dong-Gyu Jo,Dong-Gyu Jo,Justin D. Lathia,Dominic A. Siler,Srinivasulu Chigurupati,Xin Ouyang,Tim Magnus,Tim Magnus,Simonetta Camandola,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death.
Journal ArticleDOI
Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain
Manchang Liu,Yideng Liang,Srinivasulu Chigurupati,Justin D. Lathia,Mikhail V. Pletnikov,Zhaoli Sun,Michael T. Crow,Christopher A. Ross,Mark P. Mattson,Hamid Rabb +9 more
TL;DR: It is demonstrated that severe ischemic AKI induces inflammation and functional changes in the brain and targeting these pathways could reduce morbidity and mortality in critically ill patients with severe AKI.
Journal ArticleDOI
Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.
Srinivasulu Chigurupati,Mohamed R. Mughal,Eitan Okun,Eitan Okun,Soumen Das,Amit Kumar,Michael J. McCaffery,Sudipta Seal,Mark P. Mattson +8 more
TL;DR: Topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs.
Journal ArticleDOI
Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
Thiruma V. Arumugam,Sic L. Chan,Dong-Gyu Jo,Gokhan Yilmaz,Sung-Chun Tang,Sung-Chun Tang,Aiwu Cheng,Marc Gleichmann,Eitan Okun,Vishwa Deep Dixit,Srinivasulu Chigurupati,Mohamed R. Mughal,Xin Ouyang,Lucio Miele,Tim Magnus,Suresh Poosala,D. Neil Granger,Mark P. Mattson,Mark P. Mattson +18 more
TL;DR: Findings suggest that Notch signaling may be a therapeutic target for treatment of stroke and related neurodegenerative conditions.
Journal ArticleDOI
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
Thiruma V. Arumugam,Sung-Chun Tang,Justin D. Lathia,Aiwu Cheng,Mohamed R. Mughal,Srinivasulu Chigurupati,Tim Magnus,Sic L. Chan,Dong-Gyu Jo,Xin Ouyang,David P. Fairlie,Daniel N. Granger,Alexander O. Vortmeyer,Milan Basta,Mark P. Mattson +14 more
TL;DR: A major role for complement-mediated cell death in ischemic brain injury is suggested and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke is suggested.