S
Srividya Swaminathan
Researcher at Beckman Research Institute
Publications - 45
Citations - 1374
Srividya Swaminathan is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: B cell & Leukemia. The author has an hindex of 14, co-authored 35 publications receiving 1082 citations. Previous affiliations of Srividya Swaminathan include University of California, San Francisco & Post Graduate Institute of Medical Education and Research.
Papers
More filters
Journal ArticleDOI
BCL6 enables Ph + acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition
Cihangir Duy,Christian Hurtz,Christian Hurtz,Seyedmehdi Shojaee,Leandro Cerchietti,Huimin Geng,Srividya Swaminathan,Lars Klemm,Soo-Mi Kweon,Rahul Nahar,Rahul Nahar,Melanie Braig,Eugene Park,Yong-Mi Kim,Wolf-Karsten Hofmann,Sebastian Herzog,Hassan Jumaa,H. Phillip Koeffler,J. Jessica Yu,Nora Heisterkamp,Thomas G. Graeber,Hong L Wu,B. Hilda Ye,Ari Melnick,Markus Müschen,Markus Müschen +25 more
TL;DR: It is demonstrated that targeted inhibition of BCL6 leads to eradication of drug-resistant and leukaemia-initiating subclones and the discovery of a novel mechanism of drug resistance, which is based on protective feedback signalling ofLeukaemia cells in response to treatment with TKI.
Journal ArticleDOI
Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia
Srividya Swaminathan,Lars Klemm,Lars Klemm,Eugene Park,Eugene Park,Elli Papaemmanuil,Anthony M. Ford,Soo-Mi Kweon,Daniel Trageser,Brian Hasselfeld,Nadine Henke,Jana Mooster,Huimin Geng,Klaus Schwarz,Scott C. Kogan,Rafael Casellas,David G. Schatz,Michael R. Lieber,Mel Greaves,Markus Müschen +19 more
TL;DR: It is demonstrated that AID and RAG1-RAG2 drove leukemic clonal evolution with repeated exposure to inflammatory stimuli, paralleling chronic infections in childhood.
Journal ArticleDOI
Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia.
Eun Ji Gang,Yao-Te Hsieh,Jennifer Pham,Yi Zhao,Cu Nguyen,Sandra Huantes,Eugene Park,Khatija Naing,Lars Klemm,Srividya Swaminathan,Edward M. Conway,Louis M. Pelus,John D. Crispino,Charles G. Mullighan,Michael McMillan,Markus Müschen,Michael Kahn,Yong-Mi Kim +17 more
TL;DR: In this article, selective disruption of the CBP/β- and γ-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and loss of self-renewal capacity.
Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia
Eun Ji Gang,Yao-Te Hsieh,Jennifer Pham,Yi Zhao,Cu Nguyen,Sandra Huantes,Eugene Park,Khatija Naing,Lars Klemm,Srividya Swaminathan,Edward M. Conway,Louis M. Pelus,John D. Crispino,Charles G. Mullighan,Michael McMillan,Markus Müschen,Michael Kahn,Yong-Mi Kim +17 more
TL;DR: It is reported that selective disruption of the CBP/β- and γ-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and loss of self-renewal capacity.
Journal ArticleDOI
BCL6 is critical for the development of a diverse primary B cell repertoire
Cihangir Duy,J. Jessica Yu,Rahul Nahar,Srividya Swaminathan,Soo-Mi Kweon,Jose M. Polo,Ester Valls,Lars Klemm,Seyedmehdi Shojaee,Leandro Cerchietti,Wolfgang Schuh,Hans-Martin Jäck,Christian Hurtz,Parham Ramezani-Rad,Sebastian Herzog,Hassan Jumaa,H. Phillip Koeffler,H. Phillip Koeffler,Ignacio Moreno de Alborán,Ari Melnick,B. Hilda Ye,Markus Müschen +21 more
TL;DR: It is concluded that negative regulation of Arf by BCL6 is required for pre–B cell self-renewal and the formation of a diverse polyclonal B cell repertoire.