S
Seyedmehdi Shojaee
Researcher at University of California, San Francisco
Publications - 32
Citations - 1713
Seyedmehdi Shojaee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Leukemia & B cell. The author has an hindex of 16, co-authored 32 publications receiving 1456 citations. Previous affiliations of Seyedmehdi Shojaee include University of Southern California & University of Tehran.
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Journal ArticleDOI
Genome-wide Linkage Analysis of a Parkinsonian-Pyramidal Syndrome Pedigree by 500 K SNP Arrays
Seyedmehdi Shojaee,Farzad Sina,Setareh Sadat Banihosseini,Mohammad Hossein Kazemi,Reza Kalhor,Gholam Ali Shahidi,Hossein Fakhrai-Rad,Mostafa Ronaghi,Elahe Elahi +8 more
TL;DR: The results suggest that linkage in the pedigree may have been missed had the chips containing less than 100,000 SNPs across the genome been used, and the possible value of interrogating SNPs at higher densities has been considered.
Journal ArticleDOI
BCL6 enables Ph + acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition
Cihangir Duy,Christian Hurtz,Christian Hurtz,Seyedmehdi Shojaee,Leandro Cerchietti,Huimin Geng,Srividya Swaminathan,Lars Klemm,Soo-Mi Kweon,Rahul Nahar,Rahul Nahar,Melanie Braig,Eugene Park,Yong-Mi Kim,Wolf-Karsten Hofmann,Sebastian Herzog,Hassan Jumaa,H. Phillip Koeffler,J. Jessica Yu,Nora Heisterkamp,Thomas G. Graeber,Hong L Wu,B. Hilda Ye,Ari Melnick,Markus Müschen,Markus Müschen +25 more
TL;DR: It is demonstrated that targeted inhibition of BCL6 leads to eradication of drug-resistant and leukaemia-initiating subclones and the discovery of a novel mechanism of drug resistance, which is based on protective feedback signalling ofLeukaemia cells in response to treatment with TKI.
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Metabolic gatekeeper function of B-lymphoid transcription factors
Lai N. Chan,Zhengshan Chen,Daniel Braas,Jae-Woong Lee,Gang Xiao,Huimin Geng,Kadriye Nehir Cosgun,Christian Hurtz,Seyedmehdi Shojaee,Valeria Cazzaniga,Hilde Schjerven,Thomas Ernst,Andreas Hochhaus,Steven M. Kornblau,Marina Konopleva,Miles A. Pufall,Giovanni Cazzaniga,Grace Liu,Thomas A. Milne,H. Phillip Koeffler,H. Phillip Koeffler,Theodora S. Ross,Isidro Sánchez-García,Arndt Borkhardt,Keith R. Yamamoto,Ross A. Dickins,Thomas G. Graeber,Markus Müschen +27 more
TL;DR: The results provide a mechanistic explanation for the empirical finding that glucocorticoids are effective in the treatment of B-lymphoid but not myeloid malignancies.
Journal ArticleDOI
Loss of function mutations in the gene encoding latent transforming growth factor beta binding protein 2, LTBP2, cause primary congenital glaucoma
Mehrnaz Narooie-Nejad,Seyed Hassan Paylakhi,Seyedmehdi Shojaee,Zeinab Fazlali,Mozhgan Rezaei Kanavi,Naveed Nilforushan,Naveed Nilforushan,Shahin Yazdani,Farbod Babrzadeh,Fatemeh Suri,Mostafa Ronaghi,Elahe Elahi,Coro Paisán-Ruiz +12 more
TL;DR: It is reported that LTBP2 encoding latent transforming growth factor beta binding protein 2 is a PCG causing gene, confirming results recently reported.
Journal ArticleDOI
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
Zhengshan Chen,Seyedmehdi Shojaee,Maike Buchner,Huimin Geng,Jae-Woong Lee,Lars Klemm,Björn Titz,Thomas G. Graeber,Eugene Park,Ying Xim Tan,Anne B. Satterthwaite,Elisabeth Paietta,Stephen P. Hunger,Cheryl L. Willman,Ari Melnick,Mignon L. Loh,Jae U. Jung,John E. Coligan,Silvia Bolland,Tak W. Mak,Andre Limnander,Hassan Jumaa,Michael Reth,Arthur Weiss,Clifford A. Lowell,Markus Müschen +25 more
TL;DR: It is demonstrated that pharmacological hyperactivation of SYK and engagement of negative B-cell selection represents a promising new strategy to overcome drug resistance in human ALL.