S
Stefan Porubsky
Researcher at University of Mainz
Publications - 100
Citations - 2554
Stefan Porubsky is an academic researcher from University of Mainz. The author has contributed to research in topics: Kidney & Medicine. The author has an hindex of 26, co-authored 87 publications receiving 2011 citations. Previous affiliations of Stefan Porubsky include French Institute of Health and Medical Research & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans
Carmela De Santo,Mariolina Salio,S. Hajar Masri,Laurel Yong Hwa Lee,Tao Dong,Anneliese O. Speak,Stefan Porubsky,Sarah Booth,Natacha Veerapen,Gurdyal S. Besra,Hermann Josef Gröne,Frances M. Platt,Maria Zambon,Vincenzo Cerundolo +13 more
TL;DR: It is demonstrated that the absence of invariant NKT cells in mice during IAV infection resulted in the expansion of myeloid-derived suppressor cells (MDSCs), which suppressed IAV-specific immune responses through the expression of both arginase and NOS, resulting in high IAV titer and increased mortality.
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Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.
Stefan Porubsky,Anneliese O. Speak,Bruno Luckow,Vincenzo Cerundolo,Frances M. Platt,Hermann Josef Gröne +5 more
TL;DR: The results strongly suggest that iGb3 is unlikely to be an endogenous CD1d lipid ligand determining thymic iNKT selection.
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Recipient toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling
Shijun Wang,Christoph Schmaderer,Eva Kiss,Claudia Schmidt,Mahnaz Bonrouhi,Stefan Porubsky,Norbert Gretz,Liliana Schaefer,Carsten J. Kirschning,Zoran B. Popović,Hermann Josef Gröne +10 more
TL;DR: The functional relevance of TLRs and their two major signaling pathways in graft-infiltrating mononuclear cells in the pathophysiology of CAD are highlighted and a TLR signaling blockade may be a therapeutic option for the prevention of CAD.
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The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Alexander Marx,John K.C. Chan,Lara Chalabreysse,Sanja Dacic,Frank C. Detterbeck,Christopher A. French,Jason L. Hornick,Hiroshi Inagaki,Deepali Jain,Alexander J. Lazar,Mirella Marino,Edith M. Marom,Andre L. Moreira,Andrew G. Nicholson,Masayuki Noguchi,Daisuke Nonaka,Mauro Papotti,Stefan Porubsky,Lynette M. Sholl,Hisashi Tateyama,Vincent Thomas de Montpréville,William D. Travis,Arun Rajan,Anja C. Roden,Philipp Ströbel +24 more
TL;DR: The fifth edition of the WHO classification of thymic epithelial tumors (including thymomas, carcinomas, and neuroendocrine tumors [NETs]), mediastinal germ cell tumors, and mesenchymal neoplasms is presented in this paper.
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Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression.
Anna Henger,Matthias Kretzler,Matthias Kretzler,Matthias Kretzler,Peter Doran,Peter Doran,Peter Doran,Mahnaz Bonrouhi,Mahnaz Bonrouhi,Mahnaz Bonrouhi,Holger Schmid,Holger Schmid,Holger Schmid,Eva Kiss,Eva Kiss,Eva Kiss,Clemens D. Cohen,Clemens D. Cohen,Clemens D. Cohen,Stephen F. Madden,Stephen F. Madden,Stephen F. Madden,Stefan Porubsky,Stefan Porubsky,Stefan Porubsky,Elisabeth F. Gröne,Elisabeth F. Gröne,Elisabeth F. Gröne,Detlef Schlöndorff,Detlef Schlöndorff,Detlef Schlöndorff,Peter J. Nelson,Hermann Josef Gröne +32 more
TL;DR: The feasibility of gene expression-based disease categorization in human nephropathies based on the extraction of marker gene sets is suggested.