M
Maximilian J. Waldner
Researcher at University of Erlangen-Nuremberg
Publications - 137
Citations - 9027
Maximilian J. Waldner is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 35, co-authored 101 publications receiving 6463 citations. Previous affiliations of Maximilian J. Waldner include Pierre-and-Marie-Curie University & University of Mainz.
Papers
More filters
Journal ArticleDOI
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Gabriela Bindea,Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Marie Tosolini,Marie Tosolini,Marie Tosolini,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Maximilian J. Waldner,Anna C. Obenauf,Helen K. Angell,Helen K. Angell,Helen K. Angell,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Anne Berger,Patrick Bruneval,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman,Christoph Becker,Franck Pagès,Michael R. Speicher,Zlatko Trajanoski,Jérôme Galon +30 more
TL;DR: The immune landscape in human colorectal cancer is revealed and the major hallmarks of the microenvironment associated with tumor progression and recurrence are revealed.
Journal ArticleDOI
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
Claudia Günther,Eva Martini,Nadine Wittkopf,Kerstin Amann,Benno Weigmann,Helmut Neumann,Maximilian J. Waldner,Stephen M. Hedrick,Stefan Tenzer,Markus F. Neurath,Christoph Becker +10 more
TL;DR: A critical function of caspase-8 is demonstrated in regulating intestinal homeostasis and in protecting IECs from TNF-α-induced necroptotic cell death and high levels of RIP3 in human Paneth cells and increased ne croptosis in the terminal ileum of patients with Crohn’s disease are identified, suggesting a potential role of necropsies in the pathogenesis of this disease.
Journal ArticleDOI
Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
Tamar Mchedlidze,Maximilian J. Waldner,Steffen Zopf,Jennifer A. Walker,Andrew L. Rankin,Marcus Schuchmann,David Voehringer,Andrew N. J. McKenzie,Markus F. Neurath,Stefan Pflanz,Stefan Wirtz +10 more
TL;DR: It is reported that hepatic expression of interleukin-33 was both required and sufficient for severe hepatic fibrosis in vivo and support the concept of modulation of IL-33 bioactivity for therapeutic purposes.
Journal ArticleDOI
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
Mihaela Angelova,Pornpimol Charoentong,Hubert Hackl,Maria Fischer,Rene Snajder,Anne Krogsdam,Maximilian J. Waldner,Gabriela Bindea,Gabriela Bindea,Bernhard Mlecnik,Bernhard Mlecnik,Jérôme Galon,Jérôme Galon,Zlatko Trajanoski +13 more
TL;DR: The immunophenotypes of the tumors and the cancer antigenome remain widely unexplored, and the findings represent a step toward the development of personalized cancer immunotherapies.
Journal ArticleDOI
The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis
Bernhard Mlecnik,Bernhard Mlecnik,Bernhard Mlecnik,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Amos Kirilovsky,Amos Kirilovsky,Amos Kirilovsky,Helen K. Angell,Anna C. Obenauf,Marie Tosolini,Marie Tosolini,Marie Tosolini,Sarah E. Church,Sarah E. Church,Sarah E. Church,Pauline Maby,Pauline Maby,Pauline Maby,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Stéphanie Mauger,Stéphanie Mauger,Stéphanie Mauger,Maximilian J. Waldner,Anne Berger,Michael R. Speicher,Franck Pagès,Viia Valge-Archer,Jérôme Galon,Jérôme Galon,Jérôme Galon +39 more
TL;DR: The data demonstrate the protective impact of the Immunoscore, a cytotoxic immune signature, and increased marginal lymphatic vessels, against the generation of distant metastases, regardless of genomic instability.