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Stefan Wilhelm
Researcher at University of Oklahoma
Publications - 50
Citations - 7053
Stefan Wilhelm is an academic researcher from University of Oklahoma. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 20, co-authored 35 publications receiving 4704 citations. Previous affiliations of Stefan Wilhelm include University of Regensburg & University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
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The entry of nanoparticles into solid tumours
Shrey Sindhwani,Abdullah Muhammad Syed,Jessica Ngai,Benjamin R. Kingston,Laura Maiorino,Laura Maiorino,Jeremy Rothschild,Presley MacMillan,Yuwei Zhang,Netra Unni Rajesh,Tran Hoang,Jamie L. Y. Wu,Stefan Wilhelm,Anton Zilman,Suresh Gadde,Andrew Sulaiman,Ben Ouyang,Zachary Lin,Lisheng Wang,Mikala Egeblad,Warren C. W. Chan +20 more
TL;DR: The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans- endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.
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Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine.
TL;DR: An overview of the field`s understanding of how nanoparticle physicochemical properties affect cellular interactions is summarized, cellular internalization pathways are reviewed, and intracellular nanoparticle trafficking and kinetics are explored.
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Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors
Qin Dai,Stefan Wilhelm,Ding Ding,Abdullah Muhammad Syed,Shrey Sindhwani,Yuwei Zhang,Yih Yang Chen,Presley MacMillan,Warren C. W. Chan +8 more
TL;DR: It was shown that less than 14 out of 1 million intravenously administrated nanoparticles were delivered to targeted cancer cells, and that only 2 out of 100 cancer cells interacted with the nanoparticles, suggesting the need to re-evaluate the active targeting process and therapeutic mechanisms using quantitative methods.
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Elimination Pathways of Nanoparticles.
Wilson Poon,Yi-Nan Zhang,Ben Ouyang,Benjamin R. Kingston,Jamie L. Y. Wu,Stefan Wilhelm,Warren C. W. Chan +6 more
TL;DR: It is discovered that the interaction of nanoparticles with liver nonparenchymal cells determines the elimination fate, and it is shown that the removal of Kupffer cells increased fecal elimination by >10 times.