S
Steffen Daub
Researcher at University of Mainz
Publications - 23
Citations - 1136
Steffen Daub is an academic researcher from University of Mainz. The author has contributed to research in topics: Oxidative stress & Endothelial dysfunction. The author has an hindex of 11, co-authored 18 publications receiving 827 citations.
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Journal ArticleDOI
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models
Swenja Kröller-Schön,Sebastian Steven,Sabine Kossmann,Alexander Scholz,Steffen Daub,Matthias Oelze,Ning Xia,Michael Hausding,Yuliya Mikhed,Elena Zinssius,Michael Mader,Paul Stamm,Nicolai Treiber,Karin Scharffetter-Kochanek,Huige Li,Eberhard Schulz,Philip Wenzel,Thomas Münzel,Andreas Daiber +18 more
TL;DR: The data show that mtROS trigger the activation of phagocytic and cardiovascular NADPH oxidases, which may have fundamental implications for immune cell activation and development of AT-II-induced hypertension.
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Glucose Independent Improvement of Vascular Dysfunction in Experimental Sepsis by Dipeptidyl-Peptidase 4 Inhibition
Swenja Kröller-Schön,Maike Knorr,Michael Hausding,Matthias Oelze,Alexandra Schuff,Richard Schell,Stephan Sudowe,Alexander Scholz,Steffen Daub,Susanne Karbach,Sabine Kossmann,Tommaso Gori,Philip Wenzel,Eberhard Schulz,Stephan Grabbe,Thomas Klein,Thomas Münzel,Andreas Daiber +17 more
TL;DR: Linagliptin demonstrated pleiotropic vasodilatory, antioxidant, and anti-inflammatory properties independent of its glucose-lowering properties in an experimental sepsis model and might translate into cardiovascular benefits in diabetic patients.
Journal ArticleDOI
High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation
Kento Kitada,Steffen Daub,Yahua Zhang,Janet D. Klein,Daisuke Nakano,Tetyana V. Pedchenko,Louise Lantier,Lauren M. LaRocque,Adriana Marton,Patrick Neubert,Agnes Schröder,Natalia Rakova,Jonathan Jantsch,Anna Dikalova,Sergey Dikalov,David G. Harrison,Dominik N. Müller,Akira Nishiyama,Manfred Rauh,Raymond C. Harris,Friedrich C. Luft,David H. Wasserman,Jeff M. Sands,Jens Titze +23 more
TL;DR: It is demonstrated that urine concentration, and therefore regulation of water conservation, is an important control system for urine formation and extracellular volume homeostasis in mice and humans across various levels of salt intake.
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Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2).
Marin Kuntic,Matthias Oelze,Sebastian Steven,Swenja Kröller-Schön,Paul Stamm,Sanela Kalinovic,Katie Frenis,Ksenija Vujacic-Mirski,Maria Teresa Bayo Jimenez,Miroslava Kvandova,Konstantina Filippou,Ahmad Al Zuabi,Vivienne Brückl,Omar Hahad,Steffen Daub,Franco Varveri,Tommaso Gori,Regina Huesmann,Thorsten Hoffmann,Frank P. Schmidt,John F. Keaney,Andreas Daiber,Thomas Münzel +22 more
TL;DR: E-cigarette vapour exposure increases vascular, cerebral, and pulmonary oxidative stress via a NOX-2-dependent mechanism, which identifies the toxic aldehyde acrolein as a key mediator of the observed adverse vascular consequences.
Journal ArticleDOI
Increased salt consumption induces body water conservation and decreases fluid intake
Natalia Rakova,Kento Kitada,Kathrin Lerchl,Anke Dahlmann,Anna Birukov,Steffen Daub,Christoph W. Kopp,Tetyana V. Pedchenko,Yahua Zhang,Luis Beck,Bernd Johannes,Adriana Marton,Dominik N. Müller,Manfred Rauh,Friedrich C. Luft,Jens Titze +15 more
TL;DR: The projected effect of salt-driven hormone rhythm modulation corresponded well with the measured decrease in water intake and an increase in urine volume with surplus osmolyte excretion, indicating endogenous free water accrual by urine concentration.