S
Sabine Kossmann
Researcher at University of Mainz
Publications - 33
Citations - 2418
Sabine Kossmann is an academic researcher from University of Mainz. The author has contributed to research in topics: Angiotensin II & Inflammation. The author has an hindex of 18, co-authored 32 publications receiving 1929 citations. Previous affiliations of Sabine Kossmann include The Heart Research Institute.
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Journal ArticleDOI
Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Philip Wenzel,Maike Knorr,Sabine Kossmann,Jan Stratmann,Michael Hausding,Swenja Schuhmacher,Susanne Karbach,Melanie Schwenk,Nir Yogev,Eberhard Schulz,Matthias Oelze,Stephan Grabbe,Helmut Jonuleit,Christian Becker,Andreas Daiber,Ari Waisman,Thomas Münzel +16 more
TL;DR: Infiltrating monocytes with a proinflammatory phenotype and macrophages rather than neutrophils appear to be essential for ATII-induced vascular dysfunction and arterial hypertension.
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Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Susanne Karbach,Tanja Schönfelder,Inês Brandão,Eivor Wilms,Nives Hörmann,Sven Jäckel,Rebecca Schüler,Stefanie Finger,Maike Knorr,Jeremy Lagrange,Moritz Brandt,Ari Waisman,Sabine Kossmann,Katrin Schäfer,Thomas Münzel,Christoph Reinhardt,Philip Wenzel +16 more
TL;DR: Gut microbiota facilitate AngII‐induced vascular dysfunction and hypertension, at least in part, by supporting an MCP‐1/IL‐17 driven vascular immune cell infiltration and inflammation.
Journal ArticleDOI
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models
Swenja Kröller-Schön,Sebastian Steven,Sabine Kossmann,Alexander Scholz,Steffen Daub,Matthias Oelze,Ning Xia,Michael Hausding,Yuliya Mikhed,Elena Zinssius,Michael Mader,Paul Stamm,Nicolai Treiber,Karin Scharffetter-Kochanek,Huige Li,Eberhard Schulz,Philip Wenzel,Thomas Münzel,Andreas Daiber +18 more
TL;DR: The data show that mtROS trigger the activation of phagocytic and cardiovascular NADPH oxidases, which may have fundamental implications for immune cell activation and development of AT-II-induced hypertension.
Journal ArticleDOI
De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy
Baerbel Klauke,Sabine Kossmann,Anna Gaertner,Kristina Brand,Ines Stork,Andreas Brodehl,Mareike Dieding,Volker Walhorn,Dario Anselmetti,Désirée Gerdes,B. Bohms,Uwe Schulz,Edzard zu Knyphausen,Matthias Vorgerd,Jan Gummert,Hendrik Milting +15 more
TL;DR: The gene coding for desmin appears to be a novel ARVC gene, which should be included in molecular genetic screening of ARVC patients, and is found in segment 1A of the desmin rod domain.
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Glucose Independent Improvement of Vascular Dysfunction in Experimental Sepsis by Dipeptidyl-Peptidase 4 Inhibition
Swenja Kröller-Schön,Maike Knorr,Michael Hausding,Matthias Oelze,Alexandra Schuff,Richard Schell,Stephan Sudowe,Alexander Scholz,Steffen Daub,Susanne Karbach,Sabine Kossmann,Tommaso Gori,Philip Wenzel,Eberhard Schulz,Stephan Grabbe,Thomas Klein,Thomas Münzel,Andreas Daiber +17 more
TL;DR: Linagliptin demonstrated pleiotropic vasodilatory, antioxidant, and anti-inflammatory properties independent of its glucose-lowering properties in an experimental sepsis model and might translate into cardiovascular benefits in diabetic patients.