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Natalia Rakova
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 18
Citations - 1606
Natalia Rakova is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Salt intake & Excretion. The author has an hindex of 9, co-authored 18 publications receiving 1237 citations. Previous affiliations of Natalia Rakova include University of Erlangen-Nuremberg & Humboldt University of Berlin.
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Journal ArticleDOI
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
Helge Wiig,Agnes Schröder,Wolfgang Neuhofer,Jonathan Jantsch,Christoph W. Kopp,Tine V. Karlsen,Michael Boschmann,Jennifer Goss,Maija Bry,Natalia Rakova,Anke Dahlmann,Sven Brenner,Olav Tenstad,Harri Nurmi,Eero Mervaala,Hubertus Wagner,F. X. Beck,Dominik N. Müller,Dontscho Kerjaschki,Friedrich C. Luft,David G. Harrison,Kari Alitalo,Jens Titze +22 more
TL;DR: The results suggest that the skin contains a hypertonic interstitial fluid compartment in which MPS cells exert homeostatic and blood pressure-regulatory control by local organization of interstitial electrolyte clearance via TONEBP and VEGFC/VEGFR3-mediated modification of cutaneous lymphatic capillary function.
Journal ArticleDOI
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Natalia Rakova,Kathrin Jüttner,Anke Dahlmann,Agnes Schröder,Peter Linz,Christoph W. Kopp,Manfred Rauh,Ulrike Goller,Luis Beck,Alexander Agureev,Galina Vassilieva,Liubov Lenkova,Bernd Johannes,Peter Wabel,Ulrich Moissl,Jörg Vienken,Rupert Gerzer,Kai-Uwe Eckardt,Dominik N. Müller,Dominik N. Müller,Karl Kirsch,Boris Morukov,Friedrich C. Luft,Friedrich C. Luft,Jens Titze,Jens Titze +25 more
TL;DR: Changes in total-body Na(+) exhibited longer infradian rhythm periods without parallel changes in body weight and extracellular water and were directly related to urinary aldosterone excretion and inversely to urinary cortisol, suggesting rhythmic hormonal control.
Journal ArticleDOI
Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense
Jonathan Jantsch,Jonathan Jantsch,Valentin Schatz,Valentin Schatz,Diana Friedrich,Agnes Schröder,Christoph W. Kopp,Isabel Siegert,Andreas Maronna,David Wendelborn,Peter Linz,Katrina J. Binger,Matthias Gebhardt,Matthias Heinig,Matthias Heinig,Patrick Neubert,Fabian Fischer,Stefan Teufel,Stefan Teufel,Jean-Pierre David,Jean-Pierre David,Clemens Neufert,Alexander Cavallaro,Natalia Rakova,Christoph Küper,F. X. Beck,Wolfgang Neuhofer,Dominik N. Müller,Gerold Schuler,Michael Uder,Christian Bogdan,Friedrich C. Luft,Friedrich C. Luft,Jens Titze,Jens Titze +34 more
TL;DR: It is suggested that the hypertonic microenvironment could serve as a barrier to infection and increase Na(+) content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense.
Journal ArticleDOI
Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment
Kathrin Lerchl,Natalia Rakova,Anke Dahlmann,Manfred Rauh,Ulrike Goller,Mathias Basner,David F. Dinges,Luis Beck,Alexander Agureev,Irina M. Larina,Victor Baranov,Boris Morukov,Kai-Uwe Eckardt,Galina Vassilieva,Peter Wabel,Jörg Vienken,Karl Kirsch,Bernd Johannes,Alexander Krannich,Friedrich C. Luft,Jens Titze +20 more
TL;DR: It is concluded that single 24-hour urine collections at intakes ranging from 6 to 12 g salt per day were not suitable to detect a 3-g difference in individual salt intake, suggesting long-term steady-state sodium balance in men simulating a flight to Mars.
Journal ArticleDOI
High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation
Kento Kitada,Steffen Daub,Yahua Zhang,Janet D. Klein,Daisuke Nakano,Tetyana V. Pedchenko,Louise Lantier,Lauren M. LaRocque,Adriana Marton,Patrick Neubert,Agnes Schröder,Natalia Rakova,Jonathan Jantsch,Anna Dikalova,Sergey Dikalov,David G. Harrison,Dominik N. Müller,Akira Nishiyama,Manfred Rauh,Raymond C. Harris,Friedrich C. Luft,David H. Wasserman,Jeff M. Sands,Jens Titze +23 more
TL;DR: It is demonstrated that urine concentration, and therefore regulation of water conservation, is an important control system for urine formation and extracellular volume homeostasis in mice and humans across various levels of salt intake.