S
Stephan Brand
Researcher at Ludwig Maximilian University of Munich
Publications - 166
Citations - 19879
Stephan Brand is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 57, co-authored 161 publications receiving 18149 citations. Previous affiliations of Stephan Brand include Kantonsspital St. Gallen & Hochschule Hannover.
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Journal ArticleDOI
PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites
Jürgen Glas,Jürgen Glas,Julia Seiderer,Darina Czamara,Giulia Pasciuto,Julia Diegelmann,Martin Wetzke,Torsten Olszak,Torsten Olszak,Christiane Wolf,Bertram Müller-Myhsok,Tobias Balschun,Jean Paul Achkar,Jean Paul Achkar,M. Ilyas Kamboh,Andre Franke,Richard H. Duerr,Stephan Brand +17 more
TL;DR: 5p13.1 was confirmed as a major CD susceptibility locus and in silico analysis predicted rs4495224 and rs7720838 as essential parts of binding sites for the transcription factors NF-κB and XBP1 with higher binding scores for carriers of the CD risk alleles, providing an explanation of how these SNPs might contribute to increased PTGER4 expression.
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Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease.
Fabian Schnitzler,Stephan Brand,Tanja Staudinger,Simone Pfennig,Katrin Hofbauer,Julia Seiderer,Cornelia Tillack,Burkhard Göke,Thomas Ochsenkühn,Peter Lohse +9 more
TL;DR: A severe disease phenotype was observed especially in patients who are compound-heterozygous for a common and a novel CARD15 mutation, thereby theoretically covering 73.9% of the described CARD15 variants and 96.6%" of the mutated alleles.
Journal ArticleDOI
Effects of perfusion and cyclic compression on in vitro tissue engineered meniscus implants
Maximilian Petri,K. Ufer,Ionel Toma,Christoph Becher,Emmanouil Liodakis,Stephan Brand,Philipp Haas,Chaoxu Liu,Berna Richter,Carl Haasper,G. von Lewinski,M. Jagodzinski +11 more
TL;DR: Biomechanical stimulation and perfusion have impact on collagen scaffolds seeded with BMSCs and cell proliferation can be enhanced using continuous perfusion and differentiation is fostered by mechanical stimulation.
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Safety of adalimumab in Crohn's disease during pregnancy: case report and review of the literature.
Matthias Jürgens,Stephan Brand,Levent Filik,Christoph Hübener,Uwe Hasbargen,Florian Beigel,Cornelia Tillack,Burkhard Göke,Thomas Ochsenkühn,Julia Seiderer +9 more
TL;DR: In conclusion, the current data of registries and case reports do not support an increased risk for adalimumab use during pregnancy, as caution should be taken when the group of TNF-a antibodies regarding their risk in pregnancy is classified as category B drugs.
Journal ArticleDOI
Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis.
Thomas Pusl,Nadine Wild,Timo Vennegeerts,Ralf Wimmer,Burkhard Göke,Stephan Brand,Christian Rust +6 more
TL;DR: Low levels of cholestasis normally not considered harmful could advance liver injury in patients with NAFLD, as delivery of free fatty acids to the liver in nonalcoholic fatty liver disease may render hepatocytes more vulnerable to glycochenodeoxycholic acid (GCDCA)-induced apoptosis.