S
Stephan Brand
Researcher at Ludwig Maximilian University of Munich
Publications - 166
Citations - 19879
Stephan Brand is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 57, co-authored 161 publications receiving 18149 citations. Previous affiliations of Stephan Brand include Kantonsspital St. Gallen & Hochschule Hannover.
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Journal ArticleDOI
Cell differentiation dependent expressed CCR6 mediates ERK‐1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
Stephan Brand,Torsten Olszak,Florian Beigel,Joachim Diebold,Jan-Michel Otte,Soeren T. Eichhorst,Burkhard Göke,Julia Dambacher +7 more
TL;DR: CCL20 expression is increased in intestinal inflammation, while CCR6 is upregulated during cell differentiation, suggesting an important role in intestinal homeostasis and intestinal inflammation by mediating chemotaxis of IEC but also in mediating migration of CRC cells.
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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
Jürgen Glas,Julia Seiderer,Martin Wetzke,Astrid Konrad,Helga-Paula Török,Silke Schmechel,Laurian Tonenchi,Christine Grassl,Julia Dambacher,Simone Pfennig,Kerstin C. Maier,Thomas Griga,Wolfram Klein,Jörg T. Epplen,Uwe Schiemann,Christian Folwaczny,Peter Lohse,Burkhard Göke,Thomas Ochsenkühn,Bertram Müller-Myhsok,Matthias Folwaczny,Thomas Mussack,Stephan Brand +22 more
TL;DR: IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5.
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SOCS-1 and SOCS-3 inhibit IFN-α-induced expression of the antiviral proteins 2,5-OAS and MxA
George Vlotides,Astrid S Sörensen,Florian Kopp,Kathrin Zitzmann,Neziha Cengic,Stephan Brand,Reinhart Zachoval,Christoph J. Auernhammer +7 more
TL;DR: It is demonstrated that SOCS-1 and SOCs-3 proteins inhibit IFN-α-induced activation of the Jak–STAT pathway and expression of the antiviral proteins 2 ′ ,5 ′ -OAS and MxA.
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Compensatory activation of Akt in response to mTOR and Raf inhibitors - A rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
Kathrin Zitzmann,Janina von Rüden,Stephan Brand,Burkhard Göke,Jennifer Lichtl,Gerald Spöttl,Christoph J. Auernhammer +6 more
TL;DR: The data provide a rationale for dual targeting of PI(3)K-Akt-mTOR- and Ras-Raf-MEK-Erk1/2 signaling in NET disease and combined treatment with RAD001 or NVP-BEZ235 and Raf265 was more efficient than single treatment with either kinase inhibitor.
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A Novel Role for Interleukin-27 (IL-27) as Mediator of Intestinal Epithelial Barrier Protection Mediated via Differential Signal Transducer and Activator of Transcription (STAT) Protein Signaling and Induction of Antibacterial and Anti-inflammatory Proteins
Julia Diegelmann,Torsten Olszak,Torsten Olszak,Burkhard Göke,Richard S. Blumberg,Stephan Brand +5 more
TL;DR: For the first time, IL-27 is characterized as a mediator of intestinal epithelial barrier protection mediated via transcriptional activation of anti-inflammatory and antibacterial target genes.